ArticleNanoscale research letters2016
Calcium-Ion-Triggered Co-assembly of Peptide and Polysaccharide into a Hybrid Hydrogel for Drug Delivery.
Article in Nanoscale research letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 53 citations in OpenAlex.
- Electrosprayed Alginate-Fmoc Amino Acid Microcapsules for Quercetin Loading and Release.ACS omega · 2026Article
- Herb-based multicomponent carrier-free hydrogel with antipyretic and anti-inflammatory dual effects by regulating MAPK and NF-κB signaling pathway.Materials today. Bio · 2025Article
- Research Progress of Sodium Alginate-Based Hydrogels in Biomedical Engineering.Gels (Basel, Switzerland) · 2025Review
- Hydrogel Conjugation: Engineering of Hydrogels for Drug Delivery.Pharmaceutics · 2025Review
- Recent advances in glycopeptide hydrogels: design, biological functions, and biomedical applications.Frontiers in bioengineering and biotechnology · 2025Review
- Self-assembled short peptides: Recent advances and strategies for potential pharmaceutical applications.Materials today. Bio · 2023Review
- Biocompatible Short-Peptides Fibrin Co-assembled Hydrogels.ACS applied polymer materials · 2023Article
- Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos.Frontiers in bioengineering and biotechnology · 2020Review
- Composite of Peptide-Supramolecular Polymer and Covalent Polymer Comprises a New Multifunctional, Bio-Inspired Soft Material.Macromolecular rapid communications · 2019Article
- Injectable Alginate-Peptide Composite Hydrogel as a Scaffold for Bone Tissue Regeneration.Nanomaterials (Basel, Switzerland) · 2019Article
- Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives.Molecules (Basel, Switzerland) · 2019Review
- Multicomponent peptide assemblies.Chemical Society reviews · 2018Review
- A light-responsive multienzyme complex combining cascade enzymes within a peptide-based matrix.RSC advances · 2018Article
- Spatially-resolved soft materials for controlled release - hybrid hydrogels combining a robust photo-activated polymer gel with an interactive supramolecular gel.Chemical science · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a new approach to constructing a peptide-polysaccharide hybrid hydrogel via the calcium-ion-triggered co-assembly of fluorenylmethyloxycarbonyl-diphenylalanine (Fmoc-FF) peptide and alginate. Calcium ions triggered the self-assembly of Fmoc-FF peptide into nanofibers with diameter of about 30 nm. Meanwhile, alginate was rapidly crosslinked by the calcium ions, leading to the formation of stable hybrid hydrogel beads. Compared to alginate or Fmoc-FF hydrogel alone, the hybrid Fmoc-FF/alginate hydrogel had much better stability in both water and a phosphate-buffered solution (PBS), probably because of the synergistic effect of noncovalent and ionic interactions. Furthermore, docetaxel was chosen as a drug model, and it was encapsulated by hydrogel beads to study the in vitro release behavior. The sustained and controlled docetaxel release was obtained by varying the concentration ratio between Fmoc-FF peptide and alginate.
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Registered trials
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