Evidence map›Paper›PMID 27067331›Full record

ArticleAntimicrobial agents and chemotherapy2016

Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data.

Veronica N Kos, Robert E McLaughlin, Humphrey A Gardner

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Molecular characterization of clinically isolatedAntimicrobial agents and chemotherapy · 2024
    Article
  3. Article
  4. Emergence of ST463Microbiology spectrum · 2023
    Article
  5. Article
  6. Antimicrobial agents and chemotherapy · 2023
    Article
  7. Whole-Genome Sequencing Reveals Diversity of Carbapenem-ResistantAntimicrobial agents and chemotherapy · 2022
    Article
  8. Article
  9. Article
  10. Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.Journal of the American Chemical Society · 2019
    Article
  11. Whole-Genome Sequencing Accurately Identifies Resistance to Extended-Spectrum β-Lactams for Major Gram-Negative Bacterial Pathogens.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Veronica N KosInfection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, Massachusetts, USA kosscientific@gmail.com.
Robert E McLaughlinInfection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
Humphrey A GardnerEarly Clinical Development Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ceftazidime is one of the few cephalosporins with activity against Pseudomonas aeruginosa Using whole-genome comparative analysis, we set out to determine the prevalent mechanism(s) of resistance to ceftazidime (CAZ) using a set of 181 clinical isolates. These isolates represented various multilocus sequence types that consisted of both ceftazidime-susceptible and -resistant populations. A presumptive resistance mechanism against ceftazidime was identified in 88% of the nonsusceptible isolates using this approach.

Indexed as

Gene Expression Regulation, BacterialGenome, BacterialAmino Acid SequenceAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasesbeta-Lactam ResistanceCeftazidimeCitrobacter freundiiGenotypeHumansMicrobial Sensitivity TestsMultilocus Sequence TypingN-Acetylmuramoyl-L-alanine AmidasePseudomonas aeruginosaPseudomonas InfectionsAmpC beta-lactamasesAmpD protein, BacteriaAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCeftazidimeN-Acetylmuramoyl-L-alanine Amidase

Identifiers

PMID27067331
PMCPMC4879354

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.