ArticleJournal of molecular neuroscience : MN2016
DNA Methylation Profiling Reveals Correlation of Differential Methylation Patterns with Gene Expression in Human Epilepsy.
Article in Journal of molecular neuroscience : MN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Adenosine Kinase: An Epigenetic Modulator and Drug Target.Journal of inherited metabolic disease · 2025Review
- Epigenetics Modulators as Therapeutics for Neurological Disorders.Current pharmaceutical design · 2025Review
- DNA Methylation Description of Hippocampus, Cortex, Amygdala, and Blood of Drug-Resistant Temporal Lobe Epilepsy.Molecular neurobiology · 2023Article
- Article
- The potential role of DNA methylation as preventive treatment target of epileptogenesis.Frontiers in cellular neuroscience · 2022Review
- The Potential of Circulating Cell-Free DNA Methylation as an Epilepsy Biomarker.Frontiers in cellular neuroscience · 2022Review
- Is There a Relation between 677C>T Polymorphism in theBrain sciences · 2021Article
- Epigenetics and epilepsy prevention: The therapeutic potential of adenosine and metabolic therapies.Neuropharmacology · 2020Review
- Epigenetic mechanisms of neurodegenerative diseases and acute brain injury.Neurochemistry international · 2020Review
- Sarcosine Suppresses Epileptogenesis in Rats With Effects on Hippocampal DNA Methylation.Frontiers in molecular neuroscience · 2020Article
- DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures.Clinical epigenetics · 2019Article
- Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment.Journal of molecular neuroscience : MN · 2019Article
- Genome-wide DNA Methylation and RNAseq Analyses Identify Aberrant Signalling Pathways in Focal Cortical Dysplasia (FCD) Type II.Scientific reports · 2018Article
- RASgrf1, a Potential Methylatic Mediator of Anti-epileptogenesis?Neurochemical research · 2018Article
- Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury.Acta neuropathologica communications · 2018Article
- Next Generation Sequencing Methods for Diagnosis of Epilepsy Syndromes.Frontiers in genetics · 2018Review
- Association of RASgrf1 methylation with epileptic seizures.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation plays important roles in regulating gene expression and has been reported to be related with epilepsy. This study aimed to define differential DNA methylation patterns in drug-refractory epilepsy patients and to investigate the role of DNA methylation in human epilepsy. We performed DNA methylation profiling in brain tissues from epileptic and control patients via methylated-cytosine DNA immunoprecipitation microarray chip. Differentially methylated loci were validated by bisulfite sequencing PCR, and the messenger RNA (mRNA) levels of candidate genes were evaluated by reverse transcriptase PCR. We found 224 genes that showed differential DNA methylation between epileptic patients and controls. Among the seven candidate genes, three genes (TUBB2B, ATPGD1, and HTR6) showed relative transcriptional regulation by DNA methylation. TUBB2B and ATPGD1 exhibited hypermethylation and decreased mRNA levels, whereas HTR6 displayed hypomethylation and increased mRNA levels in the epileptic samples. Our findings suggest that certain genes become differentially regulated by DNA methylation in human epilepsy.
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