ArticleMolecular & cellular proteomics : MCP2016
Proteomic Identification of Putative MicroRNA394 Target Genes in Arabidopsis thaliana Identifies Major Latex Protein Family Members Critical for Normal Development.
Article in Molecular & cellular proteomics : MCP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 57 citations in OpenAlex.
- Genome-wide analysis of soybean MLPs reveals evolutionary and structural insights into drought, salt stress and ABA responses.BMC plant biology · 2025Article
- Companion cells with high florigen production express other small proteins and reveal a nitrogen-sensitiveeLife · 2025Article
- Companion cells with high florigen production express other small proteins and reveal a nitrogen-sensitivebioRxiv : the preprint server for biology · 2025Article
- miR394 and LCR cooperate with TPL to regulate AM initiation.Nature communications · 2024Article
- Morphological, histological and transcriptomic mechanisms underlying different fruit shapes inPeerJ · 2024Article
- Genome-Wide Evolutionary Characterization and Expression Analysis of Major Latex Protein (MLP) Family Genes in Tomato.International journal of molecular sciences · 2023Article
- Role of F-box E3-ubiquitin ligases in plant development and stress responses.Plant cell reports · 2023Review
- Comprehensive Analysis of Major Latex-Like Protein Family Genes in Cucumber (International journal of molecular sciences · 2023Article
- Genome-wide identification and characterization of major latex-like protein genes responsible for crop contamination in Cucurbita pepo.Molecular biology reports · 2022Article
- Contribution of Omics and Systems Biology to Plant Biotechnology.Advances in experimental medicine and biology · 2021Review
- Identification and co-evolution pattern of stem cell regulator miR394s and their targets among diverse plant species.BMC evolutionary biology · 2019Article
- Genome-wide evolutionary characterization and expression analyses of major latex protein (MLP) family genes in Vitis vinifera.Molecular genetics and genomics : MGG · 2018Article
- Quantitative proteomic analysis of the miR-148a-associated mechanisms of metastasis in non-small cell lung cancer.Oncology letters · 2018Article
- Exploration of ABA Responsive miRNAs Reveals a New Hormone Signaling Crosstalk Pathway Regulating Root Growth ofInternational journal of molecular sciences · 2018Article
- miR394 Acts as a Negative Regulator ofFrontiers in plant science · 2018Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of the F-Box protein Leaf Curling Responsiveness (LCR) is regulated by microRNA, miR394, and alterations to this interplay in Arabidopsis thaliana produce defects in leaf polarity and shoot apical meristem organization. Although the miR394-LCR node has been documented in Arabidopsis, the identification of proteins targeted by LCR F-box itself has proven problematic. Here, a proteomic analysis of shoot apices from plants with altered LCR levels identified a member of the Latex Protein (MLP) family gene as a potential LCR F-box target. Bioinformatic and molecular analyses also suggested that other MLP family members are likely to be targets for this post-translational regulation. Direct interaction between LCR F-Box and MLP423 was validated. Additional MLP members had reduction in protein accumulation, in varying degrees, mediated by LCR F-Box. Transgenic Arabidopsis lines, in which MLP28 expression was reduced through an artificial miRNA technology, displayed severe developmental defects, including changes in leaf patterning and morphology, shoot apex defects, and eventual premature death. These phenotypic characteristics resemble those of Arabidopsis plants modified to over-express LCR Taken together, the results demonstrate that MLPs are driven to degradation by LCR, and indicate that MLP gene family is target of miR394-LCR regulatory node, representing potential targets for directly post-translational regulation mediated by LCR F-Box. In addition, MLP28 family member is associated with the LCR regulation that is critical for normal Arabidopsis development.
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