Evidence map›Paper›PMID 27066959›Full record

Trial reportEuropean journal of clinical pharmacology2016

Pharmacokinetics study of mazindol in plasma, oral fluid, and urine of volunteers.

Marcella Herbstrith de Oliveira, Pâmela Cristina Lukasewicz Ferreira, Graciela Carlos, Fernanda Rodrigues Salazar, Ana Maria Bergold, Flavio Pechansky, Renata Pereira Limberger, Pedro Eduardo Fröehlich

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marcella Herbstrith de OliveiraPrograma de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do sul, Avenida Ipiranga, 2752, Santana, Porto Alegre, Rio Grande do Sul, CEP: 90610-000, Brazil.
Pâmela Cristina Lukasewicz FerreiraPrograma de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do sul, Avenida Ipiranga, 2752, Santana, Porto Alegre, Rio Grande do Sul, CEP: 90610-000, Brazil. pamlukasewicz@gmail.com.
Graciela CarlosPrograma de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do sul, Avenida Ipiranga, 2752, Santana, Porto Alegre, Rio Grande do Sul, CEP: 90610-000, Brazil.
Fernanda Rodrigues SalazarPrograma de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do sul, Avenida Ipiranga, 2752, Santana, Porto Alegre, Rio Grande do Sul, CEP: 90610-000, Brazil.
Ana Maria BergoldPrograma de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do sul, Avenida Ipiranga, 2752, Santana, Porto Alegre, Rio Grande do Sul, CEP: 90610-000, Brazil.
Flavio PechanskyCentro de Pesquisa Álcool e Drogas (CPAD), Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Álvaro Alvim, 400, Porto Alegre, Rio Grande do Sul, CEP: 90420-020, Brazil.
Renata Pereira LimbergerPrograma de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do sul, Avenida Ipiranga, 2752, Santana, Porto Alegre, Rio Grande do Sul, CEP: 90610-000, Brazil.
Pedro Eduardo FröehlichPrograma de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do sul, Avenida Ipiranga, 2752, Santana, Porto Alegre, Rio Grande do Sul, CEP: 90610-000, Brazil.
Universidade Federal do Rio Grande do Sul · BRHospital de Clínicas de Porto Alegre · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere are no pharmacokinetics studies in oral fluid reported in the literature, as well as there are no data on correlation of drug levels in plasma, urine, and oral fluid in order to propose alternative matrices to monitor the use of mazindol by drivers. The present work aimed to study, preliminarily, mazindol's pharmacokinetics in plasma and oral fluid, as well as investigate the correlation of drug levels in urine, plasma, and oral fluid.

methodBlood, urine, and oral fluid samples from seven healthy male volunteers were collected at 0, 1, 2, 4, 5, 6, 8, 10, and 24 h after administration of tablets of 2 mg mazindol and analyzed by a previously validated method by LC-MS with liquid-liquid extraction. Levels of the drug found were higher in plasma when compared with oral fluid and higher in urine in relation to plasma. The study of the mazindol's pharmacokinetics showed that the most suitable model to describe the variation of the concentration over time is the compartment open model with absorption and elimination following the first-order kinetics, and confirming literature data, drug is metabolized, being the major metabolite detected, but not quantified.

conclusionIt was not found a good correlation between the concentrations of mazindol in urine and plasma, but between plasma and oral fluid, there was a good correlation, suggesting this as an alternative matrix to plasma. However, studies involving more subjects are needed.

Indexed as

Administration, OralAdultCentral Nervous System StimulantsHealthy VolunteersHumansMaleMazindolModels, BiologicalSalivaYoung AdultCentral Nervous System StimulantsMazindolLC/MSMazindolOral fluidPharmacokineticsPlasmaUrine

Identifiers

PMID27066959
OpenAlexW2338032788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.