ArticleBMC nephrology2016
Clinico-pathological characteristics and outcomes of patients with biopsy-proven hypertensive nephrosclerosis: a retrospective cohort study.
Article in BMC nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- The effect of hemodialysis on individual retinal layer thickness.International ophthalmology · 2021Trial
- Long-term renal outcomes of patients with biopsy-proven malignant hypertension-associated renal thrombotic microangiopathy who are dialysis-independent at baseline.Renal failure · 2026Observational
- Synergistic effect of obesity on hypertensive renal arteriosclerosis in individuals without chronic kidney disease: A zero-hour biopsy-based cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Nephrosclerosis-Related Histopathological Findings by Cortical Region From a Japanese Community-Based Study.Kidney medicine · 2026Article
- Hypertensive Nephrosclerosis: Pathological Changes and Overlap with Diabetic Nephropathy.Cureus · 2025Review
- Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases.Communications medicine · 2025Article
- Serum Elabela expression is decreased in hypertensive patients and could be associated with the progression of hypertensive renal damage.European journal of medical research · 2024Article
- Nephroangiosclerosis not related to hypertension: A matter to resolve in the era of precision medicine.Journal of human hypertension · 2023Article
- Role of arterial hypertension and angiotensin II in chronic kidney disease (Review).Experimental and therapeutic medicine · 2023Review
- Clinico-Histological Features of Thrombotic Microangiopathy in Renal Biopsies: A Retrospective Study.Turk patoloji dergisi · 2022Article
- Article
- Clinical and pathological analysis of renal biopsies of elderly patients in Northeast China: a single-center study.Renal failure · 2021Article
- Normotensive and hypertensive Immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis.Renal failure · 2021Article
- The glomerular filtration barrier: a structural target for novel kidney therapies.Nature reviews. Drug discovery · 2021Review
- Clinical value of multiorgan damage in hypertensive crises: A prospective follow-up study.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Clinical Phenotypes and Long-term Prognosis in White Patients With Biopsy-Verified Hypertensive Nephrosclerosis.Kidney international reports · 2020Article
- Renal Damages in Deoxycorticosterone Acetate-Salt Hypertensive Rats: Assessment with Diffusion Tensor Imaging and T2-mapping.Molecular imaging and biology · 2020Article
- Research Progress in Acute Hypertensive Renal Injury by "Journal of translational internal medicine · 2019Review
- Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension.International journal of molecular sciences · 2019Review
- Clinicopathological Implications of Proteinuria after Long-Term Isolated Hematuria due to Thin Basement Membrane Nephropathy and Focal Segmental Glomerulosclerosis.Case reports in nephrology · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to investigate renal outcomes and their predictors in biopsy-proven hypertensive nephrosclerosis (HN) patients and to compare clinico-pathological characteristics and prognoses between benign nephrosclerosis (BN) and malignant nephrosclerosis (MN) patients.
methodsData for biopsy-proven HN patients were retrospectively analyzed. Renal survival rates and relationships between clinico-pathological characteristics and outcomes were assessed.
resultsA total of 194 patients were enrolled; the mean age at biopsy was 43.8 years, and male gender predominated (82.5 %). The median duration of hypertension was 5.0 years, and the mean systolic and diastolic blood pressures were 195 ± 37 and 126 ± 26 mmHg, respectively. The median serum creatinine (Scr) level, estimated glomerular filtration rate (eGFR), and proteinuria level were 1.61 mg/dl, 49.6 ml/min/1.73 m(2), and 0.80 g/24 h, respectively. BN and MN were found by renal biopsy in 55.2 % and 44.8 % of patients, respectively. At biopsy, MN patients were younger, and had higher median Scr and proteinuria levels, higher incidences of anemia, hypertensive heart disease and hypertensive retinopathy, and worse renal outcomes than BN patients. During a median follow-up period of 3.0 years, 36 patients (18.6 %) reached end-stage renal disease (ESRD), and the 5- and 10-year cumulative renal survival rates for HN patients were 84.5 % and 48.9 %, respectively. A decreased baseline eGFR, an increased baseline proteinuria level, anemia, increased percentage of global glomerulosclerosis and tubular atrophy and interstitial fibrosis (TAIF) were independent predictors of future ESRD.
conclusionsThe clinico-pathological characteristics and prognoses were significantly different between the MN and BN patients. The renal outcomes of HN patients were independently associated with the baseline eGFR and proteinuria level, anemia, percentage of global glomerulosclerosis and TAIF.
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