ArticleScientific reports2016
Nox Complex signal and MAPK cascade pathway are cross-linked and essential for pathogenicity and conidiation of mycoparasite Coniothyrium minitans.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Disruption ofVirulence · 2025Article
- The Function of Chitinases CmCH1 and CmCH10 in the Interaction ofInternational journal of molecular sciences · 2025Article
- The biocontrol effects and mechanisms of mycoparasiticFrontiers in microbiology · 2025Article
- Review
- Botrytis cinerea type II inhibitor of apoptosis BcBIR1 enhances the biocontrol capacity of Coniothyrium minitans.Microbial biotechnology · 2024Article
- High Throughput Identification of the Potential Antioxidant Peptides inMolecules (Basel, Switzerland) · 2022Article
- Regulation of biotic interactions and responses to abiotic stresses by MAP kinase pathways in plant pathogenic fungi.Stress biology · 2021Review
- mRNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms regulating induction of fruiting body in Ophiocordyceps sinensis.Scientific reports · 2021Article
- Mycoparasitism illuminated by genome and transcriptome sequencing ofMicrobial genomics · 2020Article
- CmAim24 Is Essential for Mitochondrial Morphology, Conidiogenesis, and Mycoparasitism inApplied and environmental microbiology · 2020Article
- Host Transcriptional Response ofFrontiers in microbiology · 2020Article
- Guttation capsules containing hydrogen peroxide: an evolutionarily conserved NADPH oxidase gains a role in wars between related fungi.Environmental microbiology · 2019Article
- Communicate and Fuse: How Filamentous Fungi Establish and Maintain an Interconnected Mycelial Network.Frontiers in microbiology · 2019Review
- Article
- The NADPH Oxidases Nox1 and Nox2 Differentially Regulate Volatile Organic Compounds, Fungistatic Activity, Plant Growth Promotion and Nutrient Assimilation inFrontiers in microbiology · 2018Article
- Functional Analysis of the Melanin-Associated GeneFrontiers in microbiology · 2018Article
- Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis.PLoS pathogens · 2017Article
- BcXYG1, a Secreted Xyloglucanase fromPlant physiology · 2017Article
- BcCFEM1, a CFEM Domain-Containing Protein with Putative GPI-Anchored Site, Is Involved in Pathogenicity, Conidial Production, and Stress Tolerance inFrontiers in microbiology · 2017Article
- Transcriptome Analyses Shed New Insights into Primary Metabolism and Regulation ofFrontiers in plant science · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The NADPH oxidase complex of a sclerotial mycoparasite Coniothyrium minitans, an important biocontrol agent against crop diseases caused by Sclerotinia sclerotiorum, was identified and its functions involved in conidiation and mycoparasitism were studied. Gene knock-out and complementary experiments indicated that CmNox1, but not CmNox2, is necessary for conidiation and parasitism, and its expression could be significantly induced by its host fungus. CmNox1 is regulated by CmRac1-CmNoxR and interacts with CmSlt2, a homolog of Saccharomyces cerevisiae Slt2 encoding cell wall integrity-related MAP kinase. In ΔCmNox1, CmSlt2-GFP fusion protein lost the ability to localize to the cell nucleus accurately. The defect of conidiation in ΔCmRac1 could be partially restored by over-expressing CmSlt2, indicating that CmSlt2 was a downstream regulatory factor of CmNox1 and was involved in conidiation and parasitism. The expressions of mycoparasitism-related genes CmPks1, Cmg1 and CH1 were suppressed in the knock-out mutants of the genes in CmNox1-CmSlt2 signal pathway when cultivated either on PDA. Therefore, our study infers that CmRac1-CmNoxR regulates CmNox1-CmSlt2 pathway in regulating conidiation and pathogenicity of C. minitans.
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