ArticleMolecular and cellular biology2016
lncRHOXF1, a Long Noncoding RNA from the X Chromosome That Suppresses Viral Response Genes during Development of the Early Human Placenta.
Article in Molecular and cellular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Diagnostic and Prognostic Value of Long Noncoding RNAs as Potential Novel Biomarkers in Intrahepatic Cholestasis of Pregnancy.BioMed research international · 2021Trial
- Whole Transcriptome Sequencing Reveals How Acupuncture and Moxibustion Increase Pregnancy Rate in Patients Undergoing In Vitro Fertilization-Embryo Transplantation.BioMed research international · 2019Trial
- Identification of host lncRNAs that impact Venezuelan equine encephalitis virus TC-83 replication.Journal of virology · 2026Article
- Exploring the ceRNA network involving AGAP2-AS1 as a novel biomarker for preeclampsia.Scientific reports · 2024Article
- A novel IFNbeta-induced long non-coding RNA ZAP-IT1 interrupts Zika virus replication in A549 cells.Virologica Sinica · 2022Article
- Review
- The lncRNAs involved in regulating the RIG-I signaling pathway.Frontiers in cellular and infection microbiology · 2022Review
- Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway.Frontiers in immunology · 2022Review
- LncRNAs in the Type I Interferon Antiviral Response.International journal of molecular sciences · 2020Review
- Regulation of signaling mediated by nucleic acid sensors for innate interferon-mediated responses during viral infection.International immunology · 2019Review
- Long noncoding RNAs and the regulation of innate immunity and host-virus interactions.Journal of leukocyte biology · 2019Review
- Linc02527 promoted autophagy in Intrahepatic cholestasis of pregnancy.Cell death & disease · 2018Article
- Long Non-coding RNAs: Regulators of Viral Infection and the Interferon Antiviral Response.Frontiers in microbiology · 2018Review
- The Opening of Pandora's Box: An Emerging Role of Long Noncoding RNA in Viral Infections.Frontiers in immunology · 2018Review
- Regulation of the Interferon Response by lncRNAs in HCV Infection.Frontiers in microbiology · 2018Review
- Control of Immune Cell Homeostasis and Function by lncRNAs.Trends in immunology · 2018Review
- Long Non-Coding RNA-Mediated Regulation of the Interferon Response: A New Perspective on a Familiar Theme.Pathogens & immunity · 2018Article
- Mechanistic Insight into Long Noncoding RNAs and the Placenta.International journal of molecular sciences · 2017Review
- In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells.Journal of visualized experiments : JoVE · 2017Article
- Immune Regulation in Pregnancy: A Matter of Perspective?Obstetrics and gynecology clinics of North America · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Long noncoding RNAs (lncRNAs) can regulate gene expression in a cell-specific fashion during development. Here, we identify a novel lncRNA from the X chromosome that we named lncRHOXF1 and which is abundantly expressed in trophectoderm and primitive endoderm cells of human blastocyst-stage embryos. lncRHOXF1 is a spliced and polyadenylated lncRNA about 1 kb in length that is found in both the nuclear and cytoplasmic compartments of in vitro differentiated human trophectoderm progenitor cells. Gain-of-function experiments in human embryonic stem cells, which normally lack lncRHOXF1 RNA, revealed that lncRHOXF1 reduced proliferation and favored cellular differentiation. lncRHOXF1 knockdown using small interfering RNAs (siRNAs) in human trophectoderm progenitors increased expression of viral response genes, including type I interferon. Sendai virus infection of human trophectoderm progenitor cells increased lncRHOXF1 RNA levels, and siRNA-mediated disruption of lncRHOXF1 during infection reduced the expression of viral response genes leading to higher virus replication. Thus, lncRHOXF1 RNA is the first example of a lncRNA that regulates the host response to viral infections in human placental progenitor cells, and we propose that it functions as a repressor of the viral response during early human development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.