Evidence map›Paper›PMID 27066730›Full record

Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2016

Design and Implementation of an Intervention Development Study: Retaining Cognition While Avoiding Late-Life Depression (ReCALL).

Ariel G Gildengers, Meryl A Butters, Steven M Albert, Stewart J Anderson, Mary Amanda Dew, Kirk Erickson, Linda Garand, Jordan F Karp, Michael H Lockovich, Jennifer Morse and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Frequency of But Not Capacity for Participation in Everyday Activities Is Associated With Cognitive Impairment in Late Life.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2021
    Article
  7. Subjective Sleep Quality and Trajectories of Interleukin-6 in Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021
    Article
  8. Article
  9. Depressive symptoms and cerebral microvascular disease in adults with Type 1 diabetes mellitus.Diabetic medicine : a journal of the British Diabetic Association · 2019
    Article
  10. Article
  11. Article
  12. Treatment Considerations for Depression Research in Older Married Couples: A Dyadic Case Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ariel G GildengersDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Meryl A ButtersDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA. Electronic address: buttersma@upmc.edu.
Steven M AlbertDepartment of Behavioral and Community Health Sciences, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA.
Stewart J AndersonDepartment of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA.
Mary Amanda DewDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Kirk EricksonDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA.
Linda GarandDepartment of Health & Community Systems, University of Pittsburgh School of Nursing, Pittsburgh, PA.
Jordan F KarpDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Michael H LockovichDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Jennifer MorseDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Charles F ReynoldsDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
RESEARCH METHODS COREP30MH090333 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F. · 2011 to 2015
$8.3M
Amyloid, White Matter Hyperintensities & Outcomes of Late-Life DepressionR01MH080240 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUTTERS, MERYL A · 2009 to 2014
$2.6M
Influence of Physical Activity and Weight Loss on Brain PlasticityR01DK095172 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2012 to 2016
$2.1M
The Effects of Bipolar Disorder and its Comorbidities on Cognition in Older AdultR01MH084921 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GILDENGERS, ARIEL GERARD · 2010 to 2014
$1.8M
Prevention of Psychiatric Morbidity in AD CaregiversK23MH070719 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GARAND, LINDA · 2005 to 2009
$628k
NCATS NIH HHS UL1 TR000005NCRR NIH HHS UL1 RR024153NIA NIH HHS P30 AG024827NIDDK NIH HHS R01 DK095172NIMH NIH HHS K23 MH070719NIMH NIH HHS P30 MH090333NIMH NIH HHS R01 MH080240NIMH NIH HHS R01 MH084921
6 · The paper itself

Abstract

objectiveTo discuss the design, rationale, and implementation of an intervention development study addressing indicated and selective prevention of depression and anxiety in individuals 60 years and older with mild cognitive impairment (MCI) and in their caregivers.

methodsIn Phase I, now completed, we developed and standardized problem-solving therapy (PST) and the combined PST + moderate-intensity physical exercise (PE) intervention to be administered to participants with MCI and their caregivers together, dyadically, with both participants working with the same interventionist in the same therapy sessions. In Phase II we have been testing the interventions against enhanced usual care (EUC) and have addressed challenges to recruitment. Randomization was to one of three cells: PST + PE, PST, or EUC.

resultsAlthough we set out to intervene dyadically, many individuals with MCI lived alone or did not have a support person who could participate in the study with them. Consequently, we modified the study to include MCI participants with and without support persons. Ninety-four participants were enrolled: 20 with MCI together with their support persons (N = 20 dyads) and 54 MCI participants without accompanying support persons. Most participants have been satisfied with the usefulness of the interventions in managing stress and cognitive problems.

conclusionPST and moderate-intensity PE are acceptable interventions for depression and anxiety prevention in older adults with MCI and their available caregivers.

Indexed as

AgedAged, 80 and overAnxietyCaregiversCognitionCognitive DysfunctionDepressionExercise TherapyFemaleHumansMaleMiddle AgedPatient SatisfactionPennsylvaniaPilot ProjectsProblem Solvingageddepression preventionmild cognitive impairmentphysical exerciseproblem-solving therapy

Identifiers

PMID27066730
PMCPMC4871778

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.