ArticleeNeuro
Atypical Social Development in Vasopressin-Deficient Brattleboro Rats.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism.Science translational medicine · 2019Trial
- The role of vasopressin deficiency in the fluid intake suppression hyper-responsivity to central glucagon-like peptide-1 in the Brattleboro rat.Physiology & behavior · 2025Article
- Altered vocal communication in adult vasopressin-deficient Brattleboro rats.Physiology & behavior · 2024Article
- Vasopressin deficiency: a hypothesized driver of both social impairment and fluid imbalance in autism spectrum disorder.Molecular psychiatry · 2024Article
- Nucleus of the lateral olfactory tract: A hub linking the water homeostasis-associated supraoptic nucleus-arginine vasopressin circuit and neocortical regions to promote social behavior under osmotic challenge.Journal of neuroendocrinology · 2023Article
- The role of glucagon-like peptide-1 (GLP-1) in fluid and food intakes in vasopressin-deficient Brattleboro rats.Physiology & behavior · 2023Article
- Neurobehavioral Profiles of Six Genetically-based Rat Models of Schizophrenia- related Symptoms.Current neuropharmacology · 2023Article
- Linking oxytocin and arginine vasopressin signaling abnormalities to social behavior impairments in Prader-Willi syndrome.Neuroscience and biobehavioral reviews · 2022Review
- Socio-behavioral dysfunction in disorders of hypothalamic-pituitary involvement: The potential role of disease-induced oxytocin and vasopressin signaling deficits.Neuroscience and biobehavioral reviews · 2022Review
- Leveraging a translational research approach to drive diagnostic and treatment advances for autism.Molecular psychiatry · 2022Review
- Gut Barrier Dysfunction and Type 2 Immunity: Implications for Compulsive Behavior.Medical hypotheses · 2022Article
- Autism-associated biomarkers: test-retest reliability and relationship to quantitative social trait variation in rhesus monkeys.Molecular autism · 2021Article
- Biological and Acoustic Sex Differences in Rat Ultrasonic Vocalization.Brain sciences · 2021Review
- Neonatal CSF vasopressin concentration predicts later medical record diagnoses of autism spectrum disorder.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Subtle sex differences in vasopressin mRNA expression in the embryonic mouse brain.Journal of neuroendocrinology · 2020Article
- Viral rescue of magnocellular vasopressin cells in adolescent Brattleboro rats ameliorates diabetes insipidus, but not the hypoaroused phenotype.Scientific reports · 2019Article
- Sex differences in auditory brainstem response audiograms from vasopressin-deficient Brattleboro and wild-type Long-Evans rats.PloS one · 2019Article
- Birth delivery mode alters perinatal cell death in the mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Dissociation of Puberty and Adolescent Social Development in a Seasonally Breeding Species.Current biology : CB · 2018Article
- Activation patterns of vasopressinergic and oxytocinergic brain regions following social play exposure in juvenile male and female rats.Journal of neuroendocrinology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Over the past 3 decades, a large body of evidence has accumulated demonstrating that the neuropeptide arginine vasopressin (AVP) plays a critical role in regulating social behavior. The overwhelming majority of this evidence comes from adults, leaving a gap in our understanding of the role of AVP during development. Here, we investigated the effect of chronic AVP deficiency on a suite of juvenile social behaviors using Brattleboro rats, which lack AVP due to a mutation in the Avp gene. Social play behavior, huddling, social investigation & allogrooming, and ultrasonic vocalizations (USVs) of male and female rats homozygous for the Brattleboro mutation (Hom) were compared with their wild-type (WT) and heterozygous (Het) littermates during same-sex, same-genotype social interactions. Male and female Hom juveniles exhibited less social play than their Het and WT littermates throughout the rise, peak, and decline of the developmental profile of play. Hom juveniles also emitted fewer prosocial 50 kHz USVs, and spectrotemporal characteristics (call frequency and call duration) of individual call types differed from those of WT and Het juveniles. However, huddling behavior was increased in Hom juveniles, and social investigation and 22 kHz USVs did not differ across genotypes, demonstrating that not all social interactions were affected in the same manner. Collectively, these data suggest that the Avp gene plays a critical role in juvenile social development.
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Registered trials
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