Evidence map›Paper›PMID 27066504›Full record

ArticleJournal of immunology research2016

Mast Cell-Derived Exosomes Promote Th2 Cell Differentiation via OX40L-OX40 Ligation.

Fei Li, Yuping Wang, Lihui Lin, Juan Wang, Hui Xiao, Jia Li, Xia Peng, Huirong Dai, Li Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Mast cell-derived extracellular vesicles in lung diseases: roles in pulmonary inflammation, immune regulation, and microenvironmental remodeling.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  3. Article
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  8. Mouse TThe Journal of allergy and clinical immunology · 2025
    Article
  9. Article
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  12. Review
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  14. Review
  15. Review
  16. Review
  17. The Role of Extracellular Vesicles in Atopic Dermatitis.International journal of molecular sciences · 2024
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Fei LiDepartment of Laboratory Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University School, Shanghai 200080, China.
Yuping WangDepartment of Laboratory Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University School, Shanghai 200080, China.
Lihui LinDepartment of Laboratory Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University School, Shanghai 200080, China.
Juan WangDepartment of Laboratory Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University School, Shanghai 200080, China.
Hui XiaoDepartment of Laboratory Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University School, Shanghai 200080, China.
Jia LiDepartment of Laboratory Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University School, Shanghai 200080, China.
Xia PengDepartment of Laboratory Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University School, Shanghai 200080, China.
Huirong DaiDepartment of Laboratory Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University School, Shanghai 200080, China.
Li LiDepartment of Laboratory Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University School, Shanghai 200080, China.
Shanghai Jiao Tong University · CNShanghai First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are nanovesicles released by different cell types, such as dendritic cells (DCs), mast cells (MCs), and tumor cells. Exosomes of different origin play a role in antigen presentation and modulation of immune response to infectious disease. In this study, we demonstrate that mast cells and CD4(+) T cells colocated in peritoneal lymph nodes from BALB/c mouse. Further, bone marrow-derived mast cells (BMMCs) constitutively release exosomes, which express CD63 and OX40L. BMMC-exosomes partially promoted the proliferation of CD4(+) T cells. BMMC-exosomes significantly enhanced the differentiation of naive CD4(+) T cells to Th2 cells in a surface contact method, and this ability was partly inhibited by the addition of anti-OX40L Ab. In conclusion, BMMC-exosomes promoted the proliferation and differentiation of Th2 cells via ligation of OX40L and OX40 between exosomes and T cells. This method represents a novel mechanism, in addition to direct cell surface contacts, soluble mediators, and synapses, to regulate T cell actions by BMMC-exosomes.

Indexed as

Cell DifferentiationAnimalsAntigen PresentationBone Marrow CellsCD4-Positive T-LymphocytesCoculture TechniquesExosomesLymph NodesMast CellsMiceMice, Inbred BALB COX40 LigandPeritoneumTh2 CellsOX40 Ligand

Identifiers

PMID27066504
PMCPMC4811108
OpenAlexW2302302162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.