ArticlePediatric gastroenterology, hepatology & nutrition2016
Stepwise Endoscopy Based on Sigmoidoscopy in Evaluating Pediatric Graft-versus-Host Disease.
Article in Pediatric gastroenterology, hepatology & nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Predictive Factors for Abnormal Diagnostic Colonoscopy Findings among Pediatric Patients: A Retrospective Cohort Study.Digestive diseases (Basel, Switzerland) · 2026Article
- Intestinal involvement in graft versus host disease in children: An overview by the ESPGHAN Gastroenterology Committee.Journal of pediatric gastroenterology and nutrition · 2025Review
- PET assessment of acute gastrointestinal graft versus host disease.Bone marrow transplantation · 2023Review
- Patterns and Grading of Gastrointestinal Graft-Versus-Host Disease: A Clinicopathologic Correlation Study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Article
- Endoscopic Approach in the Diagnosis of Gastrointestinal Acute Graft Versus Host Disease in Children.JPGN reports · 2022Article
- Effective and less invasive diagnostic strategy for gastrointestinal GVHD.Endoscopy international open · 2018Article
- Acute graft-versus-host disease of the gut: considerations for the gastroenterologist.Nature reviews. Gastroenterology & hepatology · 2017Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of our study was to establish a safe and convenient diagnostic method for acute gastrointestinal (GI) graft-versus-host disease (GVHD) in children by determining the sensitivity and negative predictive values of upper and lower endoscopic biopsies for children suspected of GI GVHD.
methodsPatients suspected of GI GVHD who received endoscopic evaluation within 100 days after stem cell transplantation and endoscopies between January 2012 and March 2014 in Seoul National University Children's Hospital were included in our study.
resultsFifteen patients with a total of 20 endoscopic procedures were included in our study. Sensitivity at the esophagus, stomach, and duodenum were 22.2%, 30.0%, and 80.0%, respectively. Negative predictive values at the esophagus, stomach, and duodenum were 22.2%, 30.0%, and 60.0%, respectively. Overall sensitivity and negative predictive values of upper endoscopic biopsy for GVHD were 77.8% and 50.0%, respectively. Overall sensitivity and negative predictive values of lower endoscopic biopsy for GVHD were 88.9% and 66.7%, respectively.
conclusionWe recommend flexible sigmoidoscopy as a safe and accurate diagnostic tool for GVHD, similar to other studies reported previously. However, if there is no evidence of GVHD on sigmoidoscopy with high index of suspicion of GI bleeding, full colonoscopy and upper endoscopy should be considered.
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