Evidence map›Paper›PMID 27066311›Full record

ArticleTranslational vision science & technology2016

Automated Segmentability Index for Layer Segmentation of Macular SD-OCT Images.

Kyungmoo Lee, Gabriëlle H S Buitendijk, Hrvoje Bogunovic, Henriët Springelkamp, Albert Hofman, Andreas Wahle, Milan Sonka, Johannes R Vingerling, Caroline C W Klaver, Michael D Abràmoff

Abstract read
In one paragraph

Article in Translational vision science & technology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. [Potential of methods of artificial intelligence for quality assurance].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kyungmoo LeeDepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA ; Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, IA, USA.
Gabriëlle H S BuitendijkDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Hrvoje BogunovicDepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA ; Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, IA, USA.
Henriët SpringelkampDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands ; Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, the Hague, the Netherlands.
Andreas WahleDepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA ; Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, IA, USA.
Milan SonkaDepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA ; Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, IA, USA ; Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Johannes R VingerlingDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Caroline C W KlaverDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Michael D AbràmoffDepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA ; Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, IA, USA ; Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, IA, USA ; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA ; Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, IA, USA ; Department of Veterans Affairs, Iowa City VA Medical Center, Iowa City, IA, USA.

Funding

Graph-Based Medical Image Segmentation in 3D and 4DR01EB004640 · NIBIB · UNIVERSITY OF IOWA · PI BUATTI, JOHN M, SONKA, MILAN · 2006 to 2022
$6.1M
Three-dimensional structure-function relationships in glaucoma from SD-OCTR01EY018853 · NEI · UNIVERSITY OF IOWA · PI ABRAMOFF, MICHAEL DAVID, KWON, YOUNG H. · 2009 to 2016
$2.6M
Low-cost, portable, computer assisted imaging for diabe*R01EY017066 · NEI · UNIVERSITY OF IOWA · PI ABRAMOFF, MICHAEL DAVID · 2005 to 2008
$1.3M
NEI NIH HHS R01 EY017066NEI NIH HHS R01 EY018853NIBIB NIH HHS R01 EB004640
6 · The paper itself

Abstract

purposeTo automatically identify which spectral-domain optical coherence tomography (SD-OCT) scans will provide reliable automated layer segmentations for more accurate layer thickness analyses in population studies.

methodsSix hundred ninety macular SD-OCT image volumes (6.0 × 6.0 × 2.3 mm

resultsThe 95% confidence interval (CI) and the area under the curve (AUC) for the QI are 0.621 to 0.805 with AUC 0.713, for the mTCI 0.673 to 0.838 with AUC 0.756, and for the SI 0.784 to 0.920 with AUC 0.852. The SI AUC is significantly larger than either the QI or mTCI AUC (

conclusionsThe segmentability index SI is well suited to identify SD-OCT scans for which successful automated intraretinal layer segmentations can be expected. TRANSLATIONAL RELEVANCE: Interpreting the quantification of SD-OCT images requires the underlying segmentation to be reliable, but standard SD-OCT quality metrics do not predict which segmentations are reliable and which are not. The segmentability index SI presented in this study does allow reliable segmentations to be identified, which is important for more accurate layer thickness analyses in research and population studies.

Indexed as

image qualityintraretinal layer segmentationretinal nerve fiber layersegmentability indexspectral-domain optical coherence tomography

Identifiers

PMID27066311
PMCPMC4824284

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.