ArticleNeural plasticity2016
Parietal Fast Sleep Spindle Density Decrease in Alzheimer's Disease and Amnesic Mild Cognitive Impairment.
Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
90 citing papers in PubMed, 5 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of Biological Sex Differences in Sleep Spindles and Slow Wave Activity in Adults With and Without Insomnia.Journal of sleep research · 2026Pooled it
- Characteristics of macroscopic sleep structure in patients with mild cognitive impairment: a systematic review.Frontiers in psychiatry · 2023Pooled it
- Sleep Quality and Aging: A Systematic Review on Healthy Older People, Mild Cognitive Impairment and Alzheimer's Disease.International journal of environmental research and public health · 2022Pooled it
- Sleep in Alzheimer's disease: a systematic review and meta-analysis of polysomnographic findings.Translational psychiatry · 2022Pooled it
- Characteristics of Sleep Structure Assessed by Objective Measurements in Patients With Amnestic Mild Cognitive Impairment: A Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Acoustic enhancement of sleep slow oscillations in mild cognitive impairment.Annals of clinical and translational neurology · 2019Trial
- Associations Between Biomarkers of Alzheimer's Disease and Sleep in Cognitively Unimpaired Older Adults.Annals of clinical and translational neurology · 2026Article
- Sleep Spindles and Slow Oscillations as Potential Biomarkers and Therapeutic Targets in Mild-to-Moderate Alzheimer's Disease.Current neurology and neuroscience reports · 2026Review
- Longitudinal Alterations in Sleep EEG Biomarkers of Memory Consolidation in Middle-Aged and Older Adults.bioRxiv : the preprint server for biology · 2026Article
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Long-term forgetting, sleep, and tau in autosomal-dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of Sleep Spindle Activity With Cognitive Decline in Early Clinical Stages of Alzheimer Disease.Neurology · 2026Article
- Circadian syndrome, not metabolic syndrome, is a significant predictor of mild cognitive impairment in middle-aged and older adults - The CHARLS survey during 2015-2018.BMC public health · 2026Article
- Sleep spindles are linked to white matter connectivity differentially in older adults with and without cognitive impairment.Brain communications · 2026Article
- Wavelet Entropy Analysis of EEG Signals During Wake and Sleep in Patients with Alzheimer's Disease: A Pilot Study.Neuropsychiatric disease and treatment · 2026Article
- Altered rhythmic and arrhythmic electroencephalographic activity during non-rapid eye movement sleep in amnestic mild cognitive impairment.Brain communications · 2026Article
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
- Contextualizing Caregiver Burden in Mild Cognitive Impairment: A Dyadic Perspective.International journal of environmental research and public health · 2025Article
- Threshold Values of Sleep Spindles Features in Healthy Adults Using Scalp-EEG and Associations With Sleep Parameters.Annals of clinical and translational neurology · 2025Observational
- Slow wave synchrony during NREM sleep tracks cognitive impairment in prodromal Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have identified two types of sleep spindles: fast (13-15 Hz) centroparietal and slow (11-13 Hz) frontal spindles. Alterations in spindle activity have been observed in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). Only few studies have separately assessed fast and slow spindles in these patients showing a reduction of fast spindle count, but the possible local specificity of this phenomenon and its relation to cognitive decline severity are not clear. Moreover, fast and slow spindle density have never been assessed in AD/MCI. We have assessed fast and slow spindles in 15 AD patients, 15 amnesic MCI patients, and 15 healthy elderly controls (HC). Participants underwent baseline polysomnographic recording (19 cortical derivations). Spindles during nonrapid eye movements sleep were automatically detected, and spindle densities of the three groups were compared in the derivations where fast and slow spindles exhibited their maximum expression (parietal and frontal, resp.). AD and MCI patients showed a significant parietal fast spindle density decrease, positively correlated with Minimental State Examination scores. Our results suggest that AD-related changes in spindle density are specific for frequency and location, are related to cognitive decline severity, and may have an early onset in the pathology development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.