Evidence map›Paper›PMID 27066202›Full record

ArticleKorean journal of anesthesiology2016

Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study.

Ji Heui Lee, Seok Hee Kang, Yunkwang Kim, Hyun Ah Kim, Bong Seog Kim

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Korean journal of anesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04891146 (The Effect of Inhalation Anesthesia and Total Intravenous Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries), which is not on this map. Cited by 91 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 4 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04891146 completednot on this mapstarted 2020, after this paper: background citation

The Effect of Inhalation Anesthesia and Total Intravenous Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries

Typeobservational_patient_registrySponsorDr Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalRan2020 to 2020Enrolled84ConditionsSystemic Immune Activation, Cancer Gi, Cancer of EndometriumArmsSystemic inflammatory immmune index
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 186 citations in OpenAlex.

  1. Pooled it
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  3. Association Between Anesthesia Delivered During Tumor Resection and Cancer Survival: a Systematic Review of a Mixed Picture with Constant Themes.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
    Pooled it
  4. Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2019
    Pooled it
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  19. Anesthesia and cancer recurrence: a narrative review.Anesthesia and pain medicine · 2024
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ji Heui LeeDepartment of Anesthesiology and Pain Medicine, Center for Breast Cancer, Korea Cancer Center Hospital, Seoul, Korea.ORCID 0000-0003-3378-588X
Seok Hee KangDepartment of Anesthesiology and Pain Medicine, Center for Breast Cancer, Korea Cancer Center Hospital, Seoul, Korea.
Yunkwang KimDepartment of Anesthesiology and Pain Medicine, Center for Breast Cancer, Korea Cancer Center Hospital, Seoul, Korea.
Hyun Ah KimDepartment of General Surgery, Center for Breast Cancer, Korea Cancer Center Hospital, Seoul, Korea.
Bong Seog KimDepartment of Hemato-oncology, Veterans Health Service Medical Center, Seoul, Korea.
National Cancer Center · USBreast Cancer Research Foundation · USVeterans Health Service Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe optimal combination of anesthetic agent and technique may have an influence on long-term outcomes in cancer surgery. In vitro and in vivo studies suggest that propofol independently reduces migration of cancer cells and metastasis. Thus, the authors retrospectively examined the link between propofol-based total intravenous anesthesia (TIVA) and recurrence or overall survival in patients undergoing modified radical mastectomy (MRM).

methodsA retrospective analysis of the electronic database of all patients undergoing MRM for breast cancer between January 2007 and December 2008 was undertaken. Patients received either propofol-based TIVA (propofol group) or sevoflurane-based anesthesia (sevoflurane group). We analyzed prognostic factors of breast cancer and perioperative factors and compared recurrence-free survival and overall survival between propofol and sevoflurane groups.

resultsA total of 363 MRMs were carried out during the period of the trial; 325 cases were suitable for analysis (173 cases of propofol group, and 152 cases of sevoflurane group). There were insignificant differences between the groups in age, weight, height, histopathologic results, surgical time, or postoperative treatment (chemotherapy, hormonal therapy, and radiotherapy). The use of opioids during the perioperative period was greater in propofol group than in sevoflurane group. Overall survival was no difference between the two groups. Propofol group showed a lower rate of cancer recurrence (P = 0.037), with an estimated hazard ratio of 0.550 (95% CI 0.311-0.973).

conclusionsThis retrospective study provides the possibility that propofol-based TIVA for breast cancer surgery can reduce the risk of recurrence during the initial 5 years after MRM.

Indexed as

Breast neoplasmsPropofolRecurrenceSevoflurane

Identifiers

PMID27066202
PMCPMC4823406
OpenAlexW2327822695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.