Evidence map›Paper›PMID 27066188›Full record

ArticleOxidative medicine and cellular longevity2016

The Influence of Probiotic Lactobacillus casei in Combination with Prebiotic Inulin on the Antioxidant Capacity of Human Plasma.

Paulina Kleniewska, Arkadiusz Hoffmann, Ewa Pniewska, Rafał Pawliczak

Registry-linked trialOpen access · hybridAbstract readControlled Clinical Trial
In one paragraph

Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04046432 (Effects of Vigiis 101-LAB on Gut Health), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04046432 nacompletednot on this mapstarted 2017, after this paper: background citation

Effects of Vigiis 101-LAB on Gut Health

TypeinterventionalSponsorSunWay Biotech Co., LTD.Ran2017 to 2018Enrolled54ConditionsGastrointestinal MicrobiomeArmsVigiis 101-LAB, Placebo
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Effect of DailyMedicina (Kaunas, Lithuania) · 2025
    Trial
  3. Trial
  4. Influence of Synbiotics on Selected Oxidative Stress Parameters.Oxidative medicine and cellular longevity · 2017
    Trial
  5. Antioxidant and Anti-Inflammatory Activities of Probiotic Strains.International journal of molecular sciences · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Effects of a Sorghum Beverage withFoods (Basel, Switzerland) · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Paulina KleniewskaDepartment of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Ulica Zeligowskiego 7/9, 90-752 Lodz, Poland.
Arkadiusz HoffmannDepartment of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Ulica Zeligowskiego 7/9, 90-752 Lodz, Poland.
Ewa PniewskaDepartment of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Ulica Zeligowskiego 7/9, 90-752 Lodz, Poland.
Rafał PawliczakDepartment of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Ulica Zeligowskiego 7/9, 90-752 Lodz, Poland.ORCID 0000-0001-6784-453X
Medical University of Lodz · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to assess whether probiotic bacteria Lactobacillus casei (4 × 10(8) CFU) influences the antioxidant properties of human plasma when combined with prebiotic Inulin (400 mg). Experiments were carried out on healthy volunteers (n = 32). Volunteers were divided according to sex (16 male and 16 female) and randomly assigned to synbiotic and control groups. Blood samples were collected before synbiotic supplementation and after 7 weeks, at the end of the study. Catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) activity, and the ferric reducing ability of plasma (FRAP) in human plasma were examined. The administration of synbiotics containing L. casei plus Inulin resulted in a significant increase in FRAP values (p = 0.00008) and CAT activity (p = 0.02) and an insignificant increase in SOD and GPx activity compared to controls. Synbiotics containing L. casei (4 × 10(8) CFU) with prebiotic Inulin (400 mg) may have a positive influence on human plasma antioxidant capacity and the activity of selected antioxidant enzymes.

Indexed as

Dietary SupplementsProbioticsAdultAntioxidantsCatalaseFemaleFerric CompoundsGlutathione PeroxidaseHumansInulinLacticaseibacillus caseiMalePrebioticsSuperoxide DismutaseSynbioticsUp-RegulationAntioxidantsCatalaseFerric CompoundsGlutathione PeroxidaseInulinPrebioticsSuperoxide Dismutase

Identifiers

PMID27066188
PMCPMC4808675
OpenAlexW2301077422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.