ArticleCommunicative & integrative biology
The stability of memories during brain remodeling: A perspective.
Article in Communicative & integrative biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- No evidence for aversive associative olfactory memory through metamorphosis in Drosophila.Biology open · 2026Article
- Reductionism in Engram Neuroscience.The European journal of neuroscience · 2026Review
- Neurophysiological measurements of planarian brain activity: a unique model for neuroscience research.Biology open · 2024Article
- Self-Improvising Memory: A Perspective on Memories as Agential, Dynamically Reinterpreting Cognitive Glue.Entropy (Basel, Switzerland) · 2024Article
- Collective intelligence: A unifying concept for integrating biology across scales and substrates.Communications biology · 2024Review
- Modelling developments in consciousness within a multidimensional framework.Neuroscience of consciousness · 2024Article
- Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory.Molecular psychiatry · 2023Review
- Metamorphosis of memory circuits ineLife · 2023Article
- The brain is not mental! coupling neuronal and immune cellular processing in human organisms.Frontiers in integrative neuroscience · 2023Article
- Learning in Transcriptional Network Models: Computational Discovery of Pathway-Level Memory and Effective Interventions.International journal of molecular sciences · 2022Article
- Plasticity in Chemical Host Plant Recognition in Herbivorous Insects and Its Implication for Pest Control.Biology · 2022Review
- Understanding the physical basis of memory: Molecular mechanisms of the engram.The Journal of biological chemistry · 2022Review
- Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds.Frontiers in systems neuroscience · 2022Article
- Bistability of somatic pattern memories: stochastic outcomes in bioelectric circuits underlying regeneration.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Modeling somatic computation with non-neural bioelectric networks.Scientific reports · 2019Article
- The brain: a concept in flux.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Booting up the organism during development: Pre-behavioral functions of the vertebrate brain in guiding body morphogenesis.Communicative & integrative biology · 2018Article
- The Synaptic Theory of Memory: A Historical Survey and Reconciliation of Recent Opposition.Frontiers in systems neuroscience · 2018Article
- Vertically- and horizontally-transmitted memories - the fading boundaries between regeneration and inheritance in planaria.Biology open · 2016Review
- Physiological controls of large-scale patterning in planarian regeneration: a molecular and computational perspective on growth and form.Regeneration (Oxford, England) · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most important features of the nervous system is memory: the ability to represent and store experiences, in a manner that alters behavior and cognition at future times when the original stimulus is no longer present. However, the brain is not always an anatomically stable structure: many animal species regenerate all or part of the brain after severe injury, or remodel their CNS toward a new configuration as part of their life cycle. This raises a fascinating question: what are the dynamics of memories during brain regeneration? Can stable memories remain intact when cellular turnover and spatial rearrangement modify the biological hardware within which experiences are stored? What can we learn from model species that exhibit both, regeneration and memory, with respect to robustness and stability requirements for long-term memories encoded in living tissues? In this Perspective, we discuss relevant data in regenerating planaria, metamorphosing insects, and hibernating ground squirrels. While much remains to be done to understand this remarkable process, molecular-level insight will have important implications for cognitive science, regenerative medicine of the brain, and the development of non-traditional computational media in synthetic bioengineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.