ArticleFrontiers in plant science2016
AtHD2D Gene Plays a Role in Plant Growth, Development, and Response to Abiotic Stresses in Arabidopsis thaliana.
Article in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53 citing papers in PubMed, 108 citations in OpenAlex.
- TIME FOR COFFEE coordinates phase separation and chromatin regulation for salt tolerance.Science advances · 2026Article
- Comparative gene network analysis reveals drought resistance mechanisms inBiochemistry and biophysics reports · 2026Article
- Roles and Mechanisms of Histone Deacetylases in Plant Abiotic Stress Responses.Antioxidants (Basel, Switzerland) · 2026Review
- Exploring the evolution of the histone deacetylase 2 (HD2) gene family in plants and the role of AtHDT4 in cadmium stress response in Arabidopsis thaliana.Plant cell reports · 2026Article
- Characterization of histone acetyltransferase and histone deacetylase genes under abiotic and hormone stresses in soybean.Frontiers in plant science · 2026Article
- Functions and Mechanisms of Histone Modifications in Plants.Annual review of plant biology · 2025Review
- Roles of Histone Acetylation and Deacetylation in Root Development.Plants (Basel, Switzerland) · 2024Review
- Mechanisms of Plant Epigenetic Regulation in Response to Plant Stress: Recent Discoveries and Implications.Plants (Basel, Switzerland) · 2024Review
- Article
- Genome-wide identification of Brassicaceae histone modification genes and their responses to abiotic stresses in allotetraploid rapeseed.BMC plant biology · 2023Article
- Genome-wide identification and expression analysis of the HD2 protein family and its response to drought and salt stress inFrontiers in plant science · 2023Article
- Comprehensive Analyses of the Histone Deacetylases Tuin (HDT) Gene Family in Brassicaceae Reveals Their Roles in Stress Response.International journal of molecular sciences · 2022Article
- MYB44-ENAP1/2 restricts HDT4 to regulate drought tolerance in Arabidopsis.PLoS genetics · 2022Article
- Comparative physiological and coexpression network analyses reveal the potential drought tolerance mechanism of peanut.BMC plant biology · 2022Article
- Genome-Wide Analysis of the HDAC Gene Family and Its Functional Characterization at Low Temperatures in Tartary Buckwheat (International journal of molecular sciences · 2022Article
- Article
- Epigenetic control of abiotic stress signaling in plants.Genes & genomics · 2022Review
- Characterization of histone deacetylases and their roles in response to abiotic and PAMPs stresses in Sorghum bicolor.BMC genomics · 2022Article
- Moving Beyond DNA Sequence to Improve Plant Stress Responses.Frontiers in genetics · 2022Review
- Cold adaptation strategies in plants-An emerging role of epigenetics and antifreeze proteins to engineer cold resilient plants.Frontiers in genetics · 2022Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The histone deacetylases play important roles in the regulation of gene expression and the subsequent control of a number of important biological processes, including those involved in the response to environmental stress. A specific group of histone deacetylase genes, HD2, is present in plants. In Arabidopsis, HD2s include HD2A, HD2B, HD2C, and HD2D. Previous research showed that HD2A, HD2B, and HD2C are more related in terms of expression and function, but not HD2D. In this report, we studied different aspects of AtHD2D in Arabidopsis with respect to plant response to drought and other abiotic stresses. Bioinformatics analysis indicates that HD2D is distantly related to other HD2 genes. Transient expression in Nicotiana benthamiana and stable expression in Arabidopsis of AtHD2D fused with gfp showed that AtHD2D was expressed in the nucleus. Overexpression of AtHD2D resulted in developmental changes including fewer main roots, more lateral roots, and a higher root:shoot ratio. Seed germination and plant flowering time were delayed in transgenic plants expressing AtHD2D, but these plants exhibited higher degrees of tolerance to abiotic stresses, including drought, salt, and cold stresses. Physiological studies indicated that the malondialdehyde (MDA) content was high in wild-type plants but in plants overexpressing HD2D the MDA level increased slowly in response to stress conditions of drought, cold, and salt stress. Furthermore, electrolyte leakage in leaf cells of wild type plants increased but remained stable in transgenic plants. Our results indicate that AtHD2D is unique among HD2 genes and it plays a role in plant growth and development regulation and these changes can modulate plant stress responses.
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