ReviewFrontiers in immunology2016
Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function.
Review in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- USP7 facilitates brain tumor survival upon glucose deprivation by regulating phosphofructokinase muscle-type nuclear translocation in mice.PLoS biology · 2026Article
- Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives.Frontiers in immunology · 2025Review
- Proteomic and phenotypic characteristics of memory-like natural killer cells for cancer immunotherapy.Journal for immunotherapy of cancer · 2024Article
- Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods.World journal of methodology · 2024Review
- Integrating multiple machine learning methods to construct glutamine metabolism-related signatures in lung adenocarcinoma.Frontiers in endocrinology · 2023Article
- TGF-β signaling in the tumor metabolic microenvironment and targeted therapies.Journal of hematology & oncology · 2022Review
- Lipid Metabolism Interplay in CRC-An Update.Metabolites · 2022Review
- Development of a Clinical Prognostic Model for Metabolism-Related Genes in Squamous Lung Cancer and Correlation Analysis of Immune Microenvironment.BioMed research international · 2022Article
- Synthetic biomarkers: a twenty-first century path to early cancer detection.Nature reviews. Cancer · 2021Review
- Regulating immune memory and reversing tumor thermotolerance through a step-by-step starving-photothermal therapy.Journal of nanobiotechnology · 2021Article
- Dickkopf-related protein 3 alters aerobic glycolysis in pancreatic cancer BxPC-3 cells, promoting CD4European journal of medical research · 2021Article
- B cells polarize pathogenic inflammatory T helper subsets through ICOSL-dependent glycolysis.Science advances · 2020Article
- Establishment of the Prognostic Index Reflecting Tumor Immune Microenvironment of Lung Adenocarcinoma Based on Metabolism-Related Genes.Journal of Cancer · 2020Article
- Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.Science (New York, N.Y.) · 2019Article
- AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging.Journal of molecular medicine (Berlin, Germany) · 2019Review
- Engineered immune cells as highly sensitive cancer diagnostics.Nature biotechnology · 2019Article
- Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy.Frontiers in oncology · 2017Review
- Review
- Valproic acid induces autophagy by suppressing the Akt/mTOR pathway in human prostate cancer cells.Oncology letters · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well recognized that the immune system and metabolism are highly integrated. In this context, multilevel interactions between metabolic system and T lymphocyte signaling and fate exist. This review will discuss different potential cell metabolism pathways involved in shaping T lymphocyte function and differentiation. We will also provide a general framework for understanding how tumor microenvironmental metabolism, associated with hypoxic stress, interferes with T-cell priming and expansion. How T-cell metabolism drives T-cell-mediated immunity and how the manipulation of metabolic programing for therapeutic purposes will be also discussed.
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Registered trials
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