ArticleFrontiers in microbiology2016
Further Spread of bla NDM-5 in Enterobacteriaceae via IncX3 Plasmids in Shanghai, China.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 72 citations in OpenAlex.
- Pulmonary and extra-pulmonary infections caused by classical and hypervirulentFrontiers in microbiology · 2025Article
- Carbapenem-resistantFrontiers in cellular and infection microbiology · 2025Article
- ESKAPE in China: epidemiology and characteristics of antibiotic resistance.Emerging microbes & infections · 2024Review
- Molecular epidemiological analysis of blaAnnals of clinical microbiology and antimicrobials · 2024Article
- VirBR, a transcription regulator, promotes IncX3 plasmid transmission, and persistence of blaNature communications · 2024Article
- Analysis of the hypovirulentMicrobiology spectrum · 2024Article
- Molecular characteristics and antimicrobial resistance profiles of Carbapenem-Resistant Klebsiella pneumoniae isolates at a tertiary hospital in Nanning, China.BMC microbiology · 2023Article
- Whole genome-based genetic insights ofMicrobiology spectrum · 2023Article
- Complete-genome sequencing and comparative genomic characterization of blaBMC genomics · 2023Article
- Characterization of NDM-5-ProducingGenes · 2023Article
- Characterization and Public Health Insights of the New Delhi Metallo-β-Lactamase-ProducingMicroorganisms · 2022Article
- Persistence and Dissemination Capacities of aAntibiotics (Basel, Switzerland) · 2022Article
- Convergence of MCR-8.2 and Chromosome-Mediated Resistance to Colistin and Tigecycline in an NDM-5-Producing ST656Frontiers in cellular and infection microbiology · 2022Article
- Evaluation of Susceptibility Testing Methods for Aztreonam and Ceftazidime-Avibactam Combination Therapy on Extensively Drug-Resistant Gram-Negative Organisms.Antimicrobial agents and chemotherapy · 2021Article
- Co-Occurrence of NDM-5 and RmtB in a Clinical Isolate ofFrontiers in cellular and infection microbiology · 2021Article
- The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes.Antibiotics (Basel, Switzerland) · 2020Review
- In vitro evaluation of double carbapenem and colistin combinations against OXA-48, NDM carbapenemase-producing colistin-resistant Klebsiella pneumoniae strains.Antimicrobial resistance and infection control · 2020Article
- Dissemination of themSphere · 2020Article
- Characterization of the IncFII-IncFIB(pB171) Plasmid CarryingInfection and drug resistance · 2020Article
- Molecular Mechanisms and Epidemiology of Carbapenem-ResistantInfection and drug resistance · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One hundred and two carbapenem-resistant Enterobacteriaceae (CRE) strains were isolated in a teaching hospital in Shanghai, China from 2012 to 2015. In a follow-up study, four New Delhi metallo-β-lactamase-5 (NDM-5)-producing strains were identified after screening these CRE strains, including 1 Klebsiella pneumoniae strain (RJ01), 1 Proteus mirabilis strain (RJ02), and 2 Escherichia coli strains (RJ03 and RJ04). All K. pneumoniae and E. coli isolates were resistant to carbapenems, third-generation cephalosporins, and piperacillin-tazobactam, but were susceptible to amikacin. No epidemiological links for either E. coli isolate were found by multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). However, MLST revealed a novel sequence type, ST2250, of the K. pneumoniae RJ01 strain. Inc types and sizes of bla NDM-5-carrying plasmids differed among the four isolates, although in P. mirabilis RJ02 and E. coli RJ03, bla NDM-5 was carried by conjugative IncX3 plasmids of nearly the same size (∼40 kb). Investigation of the genetic background of sequences flanking the bla NDM-5 gene showed that all four isolates shared the same genetic content (IS3000-ΔISAba125-IS5-bla NDM-5-ble-trpF-dsbC-IS26-ΔumuD), which was identical to that of the pNDM_MGR194 plasmid circulating in India. This is the first identification of bla NDM-5 in P. mirabilis, which suggests its further spread to Enterobacteriaceae, and indicates that IncX3 plasmids may play an important role in potentiating the spread of bla NDM.
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