ArticleFrontiers in microbiology2016
Sub-MIC Tylosin Inhibits Streptococcus suis Biofilm Formation and Results in Differential Protein Expression.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 25 citations in OpenAlex.
- Metabolomics study of the inhibitory effects of tubuloside A on Streptococcus suis biofilm.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Mechanistic Landscape and Farm to Fork Control Strategies forTransboundary and emerging diseases · 2026Review
- Comparative proteomic investigation unravels the pathobiology of Mycobacterium fortuitum biofilm.Applied microbiology and biotechnology · 2023Article
- Sub-Inhibitory Concentrations of Amoxicillin and Tylosin Affect the Biofilm Formation and Virulence ofInternational journal of environmental research and public health · 2022Article
- Innovative Perspectives on Biofilm Interactions in Poultry Drinking Water Systems and Veterinary Antibiotics Used Worldwide.Antibiotics (Basel, Switzerland) · 2022Article
- Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 6:EFSA journal. European Food Safety Authority · 2021Article
- Virulence alterations in staphylococcus aureus upon treatment with the sub-inhibitory concentrations of antibiotics.Journal of advanced research · 2021Review
- Regulatory mechanisms of sub-inhibitory levels antibiotics agent in bacterial virulence.Applied microbiology and biotechnology · 2021Review
- Rational Proteomic Analysis of a New DomesticatedFrontiers in microbiology · 2021Article
- Tylosin InhibitsFrontiers in veterinary science · 2021Article
- Article
- Study on microwave assisted extraction of chrysophanol and its intervention in biofilm formation ofRSC advances · 2019Article
- Role ofFrontiers in microbiology · 2019Article
- Methyl gallate and tylosin synergistically reduce the membrane integrity and intracellular survival of Salmonella Typhimurium.PloS one · 2019Article
- Combination of berberine and ciprofloxacin reduces multi-resistantJournal of veterinary science · 2018Article
- Subinhibitory Concentrations of Amoxicillin, Lincomycin, and Oxytetracycline Commonly Used to Treat Swine IncreaseFrontiers in microbiology · 2018Article
- Spectrum-Effect Relationships Between the Bioactive Ingredient ofFrontiers in pharmacology · 2018Article
- Inhibition ofFrontiers in pharmacology · 2018Article
- Histidine Metabolism and IGPD Play a Key Role in Cefquinome Inhibiting Biofilm Formation ofFrontiers in microbiology · 2018Article
- Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus suis (S.suis) is an important zoonotic pathogen that causes severe diseases in humans and pigs. Biofilms of S. suis can induce persistent infections that are difficult to treat. In this study, the effect of tylosin on biofilm formation of S. suis was investigated. 1/2 minimal inhibitory concentration (MIC) and 1/4 MIC of tylosin were shown to inhibit S. suis biofilm formation in vitro. By using the iTRAQ strategy, we compared the protein expression profiles of S. suis grown with sub-MIC tylosin treatment and with no treatment. A total of 1501 proteins were identified by iTRAQ. Ninety-six differentially expressed proteins were identified (Ratio > ±1.5, p < 0.05). Several metabolism proteins (such as phosphoglycerate kinase) and surface proteins (such as ABC transporter proteins) were found to be involved in biofilm formation. Our results indicated that S. suis metabolic regulation, cell surface proteins, and virulence proteins appear to be of importance in biofilm growth with sub-MIC tylosin treatment. Thus, our data revealed the rough regulation of biofilm formation that may provide a foundation for future research into mechanisms and targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.