ArticleFrontiers in psychology2016
PER1 rs3027172 Genotype Interacts with Early Life Stress to Predict Problematic Alcohol Use, but Not Reward-Related Ventral Striatum Activity.
Article in Frontiers in psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- How childhood adversity affects components of decision making.Neuroscience and biobehavioral reviews · 2025Pooled it
- Switch cost in arithmetic operations and its relation to math anxiety.Psychological research · 2025Article
- DAILY - A personalized circadianFrontiers in psychiatry · 2025Article
- Cell-type and sex-specific rhythmic gene expression in the nucleus accumbens.Molecular psychiatry · 2024Article
- Refining the scope of genetic influences on alcohol misuse through environmental stratification and gene-environment interaction.Alcohol, clinical & experimental research · 2024Article
- Adolescent circadian rhythm disruption increases reward and risk-taking.Frontiers in neuroscience · 2024Article
- The Associations of Adverse Childhood Experiences (ACEs) With Substance Use in Young Adults: A Systematic Review.Substance abuse : research and treatment · 2023Review
- Adolescent binge ethanol impacts H3K36me3 regulation of synaptic genes.Frontiers in molecular neuroscience · 2023Article
- Article
- The longitudinal stability of fMRI activation during reward processing in adolescents and young adults.NeuroImage · 2021Article
- Using Genetic Marginal Effects to Study Gene-Environment Interactions with GWAS Data.Behavior genetics · 2021Article
- Circadian-Dependent and Sex-Dependent Increases in Intravenous Cocaine Self-Administration inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Contributions of childhood abuse and neglect to reward neural substrates in adolescence.NeuroImage. Clinical · 2021Article
- Convergent Evidence for Predispositional Effects of Brain Gray Matter Volume on Alcohol Consumption.Biological psychiatry · 2020Article
- Early Life Stress Restricts Translational Reactivity in CA3 Neurons Associated With Altered Stress Responses in Adulthood.Frontiers in behavioral neuroscience · 2019Article
- Childhood Trauma and Two Stages of Alcohol Use in African American and European American Women: Findings from a Female Twin Sample.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.The American journal on addictions · 2018Review
- The effects of early life stress on reward processing.Journal of psychiatric research · 2018Review
- Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers.Acta psychiatrica Scandinavica · 2018Article
- A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus.Molecular psychiatry · 2018Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Increasing evidence suggests that the circadian and stress regulatory systems contribute to alcohol use disorder (AUD) risk, which may partially arise through effects on reward-related neural function. The C allele of the PER1 rs3027172 single nucleotide polymorphism (SNP) reduces PER1 expression in cells incubated with cortisol and has been associated with increased risk for adult AUD and problematic drinking among adolescents exposed to high levels of familial psychosocial adversity. Using data from undergraduate students who completed the ongoing Duke Neurogenetics Study (DNS) (n = 665), we tested whether exposure to early life stress (ELS; Childhood Trauma Questionnaire) moderates the association between rs3027172 genotype and later problematic alcohol use (Alcohol Use Disorders Identification Test) as well as ventral striatum (VS) reactivity to reward (card-guessing task while functional magnetic resonance imaging data were acquired). Initial analyses found that PER1 rs3027172 genotype interacted with ELS to predict both problematic drinking and VS reactivity; minor C allele carriers, who were also exposed to elevated ELS reported greater problematic drinking and exhibited greater ventral striatum reactivity to reward-related stimuli. When gene × covariate and environment × covariate interactions were controlled for, the interaction predicting problematic alcohol use remained significant (p < 0.05, corrected) while the interaction predicting VS reactivity was no longer significant. These results extend our understanding of relationships between PER1 genotype, ELS, and problematic alcohol use, and serve as a cautionary tale on the importance of controlling for potential confounders in studies of moderation including gene × environment interactions.
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Registered trials
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