ArticleFrontiers in behavioral neuroscience2016
Activation of Pyramidal Neurons in Mouse Medial Prefrontal Cortex Enhances Food-Seeking Behavior While Reducing Impulsivity in the Absence of an Effect on Food Intake.
Article in Frontiers in behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse.PloS one · 2025Article
- Social context modulates active avoidance: Contributions of the anterior cingulate cortex in male and female rats.Neurobiology of stress · 2025Article
- Dissociable Roles of the mPFC-to-VTA Pathway in the Control of Impulsive Action and Risk-Related Decision-Making in Roman High- and Low-Avoidance Rats.The international journal of neuropsychopharmacology · 2024Article
- Drug-induced change in transmitter identity is a shared mechanism generating cognitive deficits.Nature communications · 2024Article
- Maturation of cortical input to dorsal raphe nucleus increases behavioral persistence in mice.eLife · 2024Article
- Drug-induced change in transmitter identity is a shared mechanism generating cognitive deficits.Research square · 2023Article
- Prefrontal cortex melanocortin 4 receptors (MC4R) mediate food intake behavior in male mice.Physiology & behavior · 2023Article
- Selective ablation of VIP interneurons in the rodent prefrontal cortex results in increased impulsivity.PloS one · 2023Article
- Prefrontal cortical circuits in anxiety and fear: an overview.Frontiers of medicine · 2022Review
- Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex.eLife · 2021Article
- Heritable variation in locomotion, reward sensitivity and impulsive behaviors in a genetically diverse inbred mouse panel.Genes, brain, and behavior · 2021Article
- Roles for the gut microbiota in regulating neuronal feeding circuits.The Journal of clinical investigation · 2021Review
- Impact of Acute and Persistent Excitation of Prelimbic Pyramidal Neurons on Motor Activity and Trace Fear Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Nociceptin/orphanin FQ neurons in the Arcuate Nucleus and Ventral Tegmental Area Act via Nociceptin Opioid Peptide Receptor Signaling to Inhibit Proopiomelanocortin and APhysiology & behavior · 2021Article
- Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions.Molecular psychiatry · 2020Review
- Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance.eLife · 2020Article
- Region-specific effects of HIV-1 Tat on intrinsic electrophysiological properties of pyramidal neurons in mouse prefrontal cortex and hippocampus.Journal of neurophysiology · 2020Article
- VIPergic neurons of the infralimbic and prelimbic cortices control palatable food intake through separate cognitive pathways.JCI insight · 2019Article
- Homeostatic and non-homeostatic controls of feeding behavior: Distinct vs. common neural systems.Physiology & behavior · 2018Review
- A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling.Molecular psychiatry · 2018 · on this mapArticle
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
The medial prefrontal cortex (mPFC) is involved in a wide range of executive cognitive functions, including reward evaluation, decision-making, memory extinction, mood, and task switching. Manipulation of the mPFC has been shown to alter food intake and food reward valuation, but whether exclusive stimulation of mPFC pyramidal neurons (PN), which form the principle output of the mPFC, is sufficient to mediate food rewarded instrumental behavior is unknown. We sought to determine the behavioral consequences of manipulating mPFC output by exciting PN in mouse mPFC during performance of a panel of behavioral assays, focusing on food reward. We found that increasing mPFC pyramidal cell output using designer receptors exclusively activated by designer drugs (DREADD) enhanced performance in instrumental food reward assays that assess food seeking behavior, while sparing effects on affect and food intake. Specifically, activation of mPFC PN enhanced operant responding for food reward, reinstatement of palatable food seeking, and suppression of impulsive responding for food reward. Conversely, activation of mPFC PN had no effect on unconditioned food intake, social interaction, or behavior in an open field. Furthermore, we found that behavioral outcome is influenced by the degree of mPFC activation, with a low drive sufficient to enhance operant responding and a higher drive required to alter impulsivity. Additionally, we provide data demonstrating that DREADD stimulation involves a nitric oxide (NO) synthase dependent pathway, similar to endogenous muscarinic M3 receptor stimulation, a finding that provides novel mechanistic insight into an increasingly widespread method of remote neuronal control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.