ArticleFrontiers in systems neuroscience2016
State-Dependent Propagation of Neuronal Sub-Population in Spontaneous Synchronized Bursts.
Article in Frontiers in systems neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Emergence of Deviance Detection in Cortical Cultures Through Maturation, Criticality, and Early Experience.The European journal of neuroscience · 2026Article
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
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- Deviance detection and regularity sensitivity in dissociated neuronal cultures.Frontiers in neural circuits · 2025Article
- Emergent functions of noise-driven spontaneous activity: homeostatic maintenance of criticality and memory consolidation.Frontiers in neural circuits · 2025Article
- Learning populations with hubs govern the initiation and propagation of spontaneous bursts in neuronal networks after learning.Frontiers in neuroscience · 2022Article
- Super-Selective Reconstruction of Causal and Direct Connectivity With Application toFrontiers in neuroscience · 2021Article
- Induction of activity synchronization among primed hippocampal neurons out of random dynamics is key for trace memory formation and retrieval.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Technologies to Study Action Potential Propagation With a Focus on HD-MEAs.Frontiers in cellular neuroscience · 2019Article
- State-dependent representation of stimulus-evoked activity in high-density recordings of neural cultures.Scientific reports · 2018Article
- Inflammatory cytokine-induced changes in neural network activity measured by waveform analysis of high-content calcium imaging in murine cortical neurons.Scientific reports · 2017Article
- Neurobiological mechanisms of state-dependent learning.Current opinion in neurobiology · 2017Review
- Development of neural population activity toward self-organized criticality.Neuroscience · 2017Article
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3 authors.
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Abstract
Repeating stable spatiotemporal patterns emerge in synchronized spontaneous activity in neuronal networks. The repertoire of such patterns can serve as memory, or a reservoir of information, in a neuronal network; moreover, the variety of patterns may represent the network memory capacity. However, a neuronal substrate for producing a repertoire of patterns in synchronization remains elusive. We herein hypothesize that state-dependent propagation of a neuronal sub-population is the key mechanism. By combining high-resolution measurement with a 4096-channel complementary metal-oxide semiconductor (CMOS) microelectrode array (MEA) and dimensionality reduction with non-negative matrix factorization (NMF), we investigated synchronized bursts of dissociated rat cortical neurons at approximately 3 weeks in vitro. We found that bursts had a repertoire of repeating spatiotemporal patterns, and different patterns shared a partially similar sequence of sub-population, supporting the idea of sequential structure of neuronal sub-populations during synchronized activity. We additionally found that similar spatiotemporal patterns tended to appear successively and periodically, suggesting a state-dependent fluctuation of propagation, which has been overlooked in existing literature. Thus, such a state-dependent property within the sequential sub-population structure is a plausible neural substrate for performing a repertoire of stable patterns during synchronized activity.
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