ArticleFrontiers in neuroscience2016
Rehabilitative Interventions and Brain Plasticity in Autism Spectrum Disorders: Focus on MRI-Based Studies.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Diagnostic Potential of Eye Tracking to Detect Autism Spectrum Disorder in Children: A Systematic Review.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Analyzing the influence of physical exercise interventions on social skills in children with autism spectrum disorder: insights from meta-analysis.Frontiers in psychology · 2024Pooled it
- A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism.Autism : the international journal of research and practice · 2023Trial
- From word reading to multisentence comprehension: Improvements in brain activity in children with autism after reading intervention.NeuroImage. Clinical · 2017Trial
- Effectiveness of the Early Start Denver Model (ESDM) as an early intervention for young children with autism spectrum disorder in clinical settings in Japan: A non-randomized controlled trial.PCN reports : psychiatry and clinical neurosciences · 2026Article
- A critical period for paired-housing-dependent autistic-like behaviors attenuation in a prenatal valproic acid-induced male mouse model of autism.Frontiers in neuroscience · 2024Article
- Structural Brain Imaging Biomarkers of Autism Spectrum Disorder.Advances in neurobiology · 2024Review
- Social Deficits or Interactional Differences? Interrogating Perspectives on Social Functioning in Autism.Frontiers in psychiatry · 2022Article
- The Role of Cholesterol and Fatty Acids in the Etiology and Diagnosis of Autism Spectrum Disorders.International journal of molecular sciences · 2021Review
- Acceptability of the Transitional Wearable Companion "+Frontiers in psychology · 2020Article
- Observational
- Computational modeling of interventions for developmental disorders.Psychological review · 2019Article
- Acceptability of the Transitional Wearable Companion "+me" in Typical Children: A Pilot Study.Frontiers in psychology · 2019Article
- Back-translating behavioral intervention for autism spectrum disorders to mice with blunted reward restores social abilities.Translational psychiatry · 2018Article
- Article
- An integrated EEG and eye-tracking approach for the study of responding and initiating joint attention in Autism Spectrum Disorders.Scientific reports · 2017Article
- Examining the Dominant Presence of Brain Grey Matter in Autism During Functional Magnetic Resonance Imaging.Basic and clinical neuroscienceReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical and research evidence supports the efficacy of rehabilitative intervention for improving targeted skills or global outcomes in individuals with autism spectrum disorder (ASD). However, putative mechanisms of structural and functional brain changes are poorly understood. This review aims to investigate the research literature on the neural circuit modifications after non-pharmacological intervention. For this purpose, longitudinal studies that used magnetic resonance imaging (MRI)-based techniques at the start and at the end of the trial to evaluate the neural effects of rehabilitative treatment in subjects with ASD were identified. The six included studies involved a limited number of patients in the active group (from 2 to 16), and differed by acquisition method (task-related and resting-state functional MRI) as well as by functional MRI tasks. Overall, the results produced by the selected investigations demonstrated brain plasticity during the treatment interval that results in an activation/functional connectivity more similar to those of subjects with typical development (TD). Repeated MRI evaluation may represent a promising tool for the detection of neural changes in response to treatment in patients with ASD. However, large-scale randomized controlled trials after standardized rehabilitative intervention are required before translating these preliminary results into clinical use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.