ArticleMetabolomics : Official journal of the Metabolomic Society
Metabolomics reveals effects of maternal smoking on endogenous metabolites from lipid metabolism in cord blood of newborns.
Article in Metabolomics : Official journal of the Metabolomic Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Examining the predictive accuracy of metabolomics for small-for-gestational-age babies: a systematic review.BMJ open · 2019Pooled it
- Metabolomic alterations in cord blood improve the prediction of childhood-onset neurodevelopmental disorders.Translational psychiatry · 2026Article
- Early-life proteomic and microbiome features signal obesity risk across 26 years of follow-up.mSystems · 2026Article
- Newborn metabolomic perturbations associated with prenatal tobacco smoke exposure and early birth.Communications medicine · 2026Article
- Evaluating neonatal cord serum metabolome in association with adolescent cardiometabolic risk factors.Pediatric research · 2026Article
- M-CSF, inducing CD163 macrophages, is associated with severity and prognosis of glomerulonephritis in microscopic polyangiitis.Arthritis research & therapy · 2025Article
- Oxidative Stress-Related Metabolomic Alterations in Pregnancy: Evidence from Exposure to Air Pollution, Metals/Metalloid, and Tobacco Smoke.Antioxidants (Basel, Switzerland) · 2025Review
- An untargeted metabolome-wide association study of maternal perinatal tobacco smoking in newborn blood spots.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Associations between Smoking and Smoking Cessation during Pregnancy and Newborn Metabolite Concentrations: Findings from PRAMS and INSPIRE Birth Cohorts.Metabolites · 2023Article
- Untargeted metabolomics unravel serum metabolic alterations in smokers with hypertension.Frontiers in physiology · 2023Article
- Fetal Exposure to Maternal Smoking and Neonatal Metabolite Profiles.Metabolites · 2022Article
- Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight.International journal of obesity (2005) · 2022Article
- High-resolution metabolomics of exposure to tobacco smoke during pregnancy and adverse birth outcomes in the Atlanta African American maternal-child cohort.Environmental pollution (Barking, Essex : 1987) · 2022Article
- Metabolic Signatures of the Exposome-Quantifying the Impact of Exposure to Environmental Chemicals on Human Health.Metabolites · 2020Review
- Influence of Second-Hand Smoke and Prenatal Tobacco Smoke Exposure on Biomarkers, Genetics and Physiological Processes in Children-An Overview in Research Insights of the Last Few Years.International journal of environmental research and public health · 2020Review
- Metabolic changes in early neonatal life: NMR analysis of the neonatal metabolic profile to monitor postnatal metabolic adaptations.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Integrating -Omics Approaches into Human Population-Based Studies of Prenatal and Early-Life Exposures.Current environmental health reports · 2018Review
- Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA general detrimental effect of smoking during pregnancy on the health of newborn children is well-documented, but the detailed mechanisms remain elusive.
objectivesBeside the specific influence of environmental tobacco smoke derived toxicants on developmental regulation the impact on the metabolism of newborn children is of particular interest, first as a general marker of foetal development and second due to its potential predictive value for the later occurrence of metabolic diseases.
methodsTobacco smoke exposure information from a questionnaire was confirmed by measuring the smoking related metabolites S-Phenyl mercapturic acid, S-Benzyl mercapturic acid and cotinine in maternal urine by LC-MS/MS. The impact of smoking on maternal endogenous serum metabolome and children's cord blood metabolome was assessed in a targeted analysis of 163 metabolites by an LC-MS/MS based assay. The anti-oxidative status of maternal serum samples was analysed by chemoluminiscence based method.
resultsHere we present for the first time results of a metabolomic assessment of the cordblood of 40 children and their mothers. Several analytes from the group of phosphatidylcholines, namely PCaaC28:1, PCaaC32:3, PCaeC30:1, PCaeC32:2, PCaeC40:1, and sphingomyelin SM C26:0, differed significantly in mothers and children's sera depending on smoking status. In serum of smoking mothers the antioxidative capacity of water soluble compounds was not significantly changed while there was a significant decrease in the lipid fraction.
conclusionOur data give evidence that smoking during pregnancy alters both the maternal and children's metabolome. Whether the different pattern found in adults compared to newborn children could be related to different disease outcomes should be in the focus of future studies.
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