ReviewFrontiers in immunology2016
Exploring the Homeostatic and Sensory Roles of the Immune System.
Review in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of fecal microbiota transplantation in metabolic syndrome: A meta-analysis of randomized controlled trials.PloS one · 2023Pooled it
- The Neuroimmunology of Autism.Molecular neurobiology · 2025Review
- Psychological Stress Reduces the Effectiveness of Periodontal Treatment: A Systematic Review.Journal of clinical medicine · 2025Review
- Divergent B-cell and cytotoxic TNK cell activation signatures in HLA-B27-associated ankylosing spondylitis and acute anterior uveitis.Frontiers in immunology · 2025Article
- Neurodivergence, intersectionality, and eating disorders: a lived experience-led narrative review.Journal of eating disorders · 2024Review
- Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer's Disease.International journal of molecular sciences · 2024Article
- Current challenges in the discovery of treatments against Mayaro fever.Expert opinion on therapeutic targets · 2024Review
- 5-methylthiopentyl Isothiocyanate, a Sulforaphane Analogue, Inhibits Pro-inflammatory Cytokines by Regulating LPS/ATP-mediated NLRP3 Inflammasome Activation.Current pharmaceutical biotechnology · 2024Article
- Cytokines, synaptic plasticity and network dynamics: a matter of balance.Neural regeneration research · 2023Review
- Transcriptional profiling of a fungal granuloma reveals a low metabolic activity ofFrontiers in cellular and infection microbiology · 2023Article
- Vital role for primary healthcare providers: urgent need to educate the community about daily nutritional self-care to support immune function and maintain health.BMJ nutrition, prevention & health · 2023Review
- Modulatory effects of R10 fraction of garlic (Allium sativum L.) on hormonal levels, T cell polarization, and fertility-related genes in mice model of polycystic ovarian syndrome.Journal of ovarian research · 2022Article
- Sciatic-Vagal Nerve Stimulation by Electroacupuncture Alleviates Inflammatory Arthritis in Lyme Disease-Susceptible C3H Mice.Frontiers in immunology · 2022Article
- Targeting CXCL12/CXCR4 Signaling with AMD3100 Might Selectively Suppress CXCR4+ T-Cell Chemotaxis Leading to the Alleviation of Chronic Prostatitis.Journal of inflammation research · 2022Article
- Adaptive homeostasis and the p53 isoform network.EMBO reports · 2021Review
- Anti-Inflammatory Effects ofPlants (Basel, Switzerland) · 2021Article
- Aerobic Training Modulates the Increase in Plasma Concentrations of Cytokines in response to a Session of Exercise.Journal of environmental and public health · 2021Article
- Severe COVID-19: understanding the role of immunity, endothelium, and coagulation in clinical practice.Jornal vascular brasileiro · 2020Review
- Vascular Endothelial Cells and Innate Immunity.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunology developed under the notion of the immune system exists to fight pathogens. Recently, the discovery of interactions with commensal microbiota that are essential to human health initiated a change in this old paradigm. Here, we argue that the immune system has major physiological roles extending far beyond defending the host. Immune and inflammatory responses share the core property of sensing, defining the immune system also as a sensory system. The inference with the immune system collects, interprets, and stores information, while creating an identity of self, places it in close relationship to the nervous system, which suggests that these systems may have a profound evolutionary connection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.