Evidence map›Paper›PMID 27065162›Full record

ReviewComprehensive Physiology2016

PTH and Vitamin D.

Syed Jalal Khundmiri, Rebecca D Murray, Eleanor Lederer

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Comprehensive Physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06199102 (The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants. A Randomized Controlled Study.), which is not on this map. Cited by 172 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06199102 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants. A Randomized Controlled Study.

TypeinterventionalSponsorPrincess Anna Mazowiecka Hospital, Warsaw, PolandRan2024 to 2027Enrolled130ConditionsVitamin D Deficiency, Osteopenia of Prematurity, Nephrolithiasis, Metabolic Bone DiseaseArmscholecalciferol/ Devikap
3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 8 syntheses or guidelines pooled it, 290 citations in OpenAlex.

  1. Pooled it
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  12. Effect of 12-Week BMI-Based Vitamin DInternational journal of molecular sciences · 2023
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  17. Interaction between vitamin D and the growth hormone/insulin-like growth factor 1 axis in children: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Syed Jalal KhundmiriDepartment of Medicine, University of Louisville, Louisville, Kentucky, USA.
Rebecca D MurrayDepartment of Medicine, University of Louisville, Louisville, Kentucky, USA.
Eleanor LedererDepartment of Medicine, University of Louisville, Louisville, Kentucky, USA.
University of Louisville · USLouisville VA Medical Center · US

Funding

Dopamine-mediated regulation of blood pressure in aging: Role of NHERF-1R21AG047474 · NIA · UNIVERSITY OF LOUISVILLE · PI KHUNDMIRI, SYED J · 2014 to 2015
$407k
BLRD VA I01 BX000610NIA NIH HHS R21 AG047474
6 · The paper itself

Abstract

PTH and Vitamin D are two major regulators of mineral metabolism. They play critical roles in the maintenance of calcium and phosphate homeostasis as well as the development and maintenance of bone health. PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion. The major function of PTH and major physiologic regulator is circulating ionized calcium. The effects of PTH on gut, kidney, and bone serve to maintain serum calcium within a tight range. PTH has a reciprocal effect on phosphate metabolism. In contrast, vitamin D has a stimulatory effect on both calcium and phosphate homeostasis, playing a key role in providing adequate mineral for normal bone formation. Both hormones act in concert with the more recently discovered FGF23 and klotho, hormones involved predominantly in phosphate metabolism, which also participate in this closely knit feedback circuit. Of great interest are recent studies demonstrating effects of both PTH and vitamin D on the cardiovascular system. Hyperparathyroidism and vitamin D deficiency have been implicated in a variety of cardiovascular disorders including hypertension, atherosclerosis, vascular calcification, and kidney failure. Both hormones have direct effects on the endothelium, heart, and other vascular structures. How these effects of PTH and vitamin D interface with the regulation of bone formation are the subject of intense investigation.

Indexed as

AnimalsCalciumFibroblast Growth Factor-23HumansParathyroid DiseasesParathyroid HormoneReceptors, CalcitriolReceptors, Parathyroid HormoneVitamin DVitamin D DeficiencyCalciumFGF23 protein, humanFibroblast Growth Factor-23Parathyroid HormoneReceptors, CalcitriolReceptors, Parathyroid HormoneVitamin D

Identifiers

PMID27065162
PMCPMC11163478
OpenAlexW2303998986

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.