Evidence map›Paper›PMID 27065108›Full record

ArticleJournal of the International AIDS Society2016

Assessing the HIV Care Continuum in Latin America: progress in clinical retention, cART use and viral suppression.

Peter F Rebeiro, Carina Cesar, Bryan E Shepherd, Raquel B De Boni, Claudia P Cortés, Fernanda Rodriguez, Pablo Belaunzarán-Zamudio, Jean W Pape, Denis Padgett, Daniel Hoces and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the International AIDS Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The HIV care cascade in Buenos Aires, Argentina: results in a tertiary referral hospital.Revista panamericana de salud publica = Pan American journal of public health · 2016
    Article
  15. Reproductive health syndemics impact retention in care among women living with HIV in Rio de Janeiro, Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 7 countries.

Peter F RebeiroDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA; p.rebeiro@vanderbilt.edu.
Carina CesarFundación Huésped, Buenos Aires, Argentina.
Bryan E ShepherdDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA.
Raquel B De BoniInstituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Claudia P CortésFundación Arriarán, Universidad de Chile, Santiago, Chile.
Fernanda RodriguezFundación Arriarán, Universidad de Chile, Santiago, Chile.
Pablo Belaunzarán-ZamudioDepartamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Jean W PapeLe Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port-au-Prince, Haiti.
Denis PadgettInstituto Hondureño de Seguridad Social and Hospital Escuela, Tegucigalpa, Honduras.
Daniel HocesInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Catherine C McGowanDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA.
Pedro CahnFundación Huésped, Buenos Aires, Argentina.
Fundación Huésped · ARUniversity of Chile · CLVanderbilt University · USGheskio Centers · HTInstituto Evandro Chagas · BRInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXUniversidad Peruana Cayetano Heredia · PEZero to Three · US

Funding

CCASAnet: Caribbean, Central and South America NetworkU01AI069923 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Pedro Enrique Cahn, Jessica L Castilho · 2006 to 2026
$41.6M
NIAID NIH HHS U01 AI069923NIAID NIH HHS U01-AI069923-09
6 · The paper itself

Abstract

introductionWe assessed trends in HIV Care Continuum outcomes associated with delayed disease progression and reduced transmission within a large Latin American cohort over a decade: clinical retention, combination antiretroviral therapy (cART) use and viral suppression (VS).

methodsAdults from Caribbean, Central and South America network for HIV epidemiology clinical cohorts in seven countries contributed data between 2003 and 2012. Retention was defined as two or more HIV care visits annually, >90 days apart. cART was defined as prescription of three or more antiretroviral agents annually. VS was defined as HIV-1 RNA <200 copies/mL at last measurement annually. cART and VS denominators were subjects with at least one visit annually. Multivariable modified Poisson regression was used to assess temporal trends and examine associations between age, sex, HIV transmission mode, cohort, calendar year and time in care.

resultsAmong 18,799 individuals in retention analyses, 14,380 in cART analyses and 13,330 in VS analyses, differences existed between those meeting indicator definitions versus those not by most characteristics. Retention, cART and VS significantly improved from 2003 to 2012 (63 to 77%, 74 to 91% and 53 to 82%, respectively; p<0.05, each). Female sex (risk ratio (RR)=0.97 vs. males) and injection drug use as HIV transmission mode (RR=0.83 vs. male sexual contact with males (MSM)) were significantly associated with lower retention, but unrelated with cART or VS. MSM (RR=0.96) significantly decreased the probability of cART compared with heterosexual transmission.

conclusionsHIV Care Continuum outcomes improved over time in Latin America, though disparities for vulnerable groups remain. Efforts must be made to increase retention, cART and VS, while engaging in additional research to sustain progress in these settings.

Indexed as

Continuity of Patient CareAdultAnti-HIV AgentsCD4 Lymphocyte CountDrug Therapy, CombinationFemaleHIV InfectionsHumansLatin AmericaMaleViral LoadAnti-HIV AgentscART usecohort studiesHIV Care ContinuumLatin Americaretentionviral suppression

Identifiers

PMID27065108
PMCPMC4827101
OpenAlexW2329496079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.