Evidence map›Paper›PMID 27065099›Full record

ArticleHuman vaccines & immunotherapeutics2016

Responses to hepatitis B vaccine in isolated anti-HBc positive adults.

Jun Yao, Wen Ren, Yongdi Chen, Zhenggang Jiang, Lingzhi Shen, Huan Shan, Xuewei Dai, Jing Li, Ying Liu, Yan Qiu and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jun Yaoa Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Wen Renb General Practice Department , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
Yongdi Chena Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Zhenggang Jianga Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Lingzhi Shena Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Huan Shanc Zhejiang Provincial Hospital , Hangzhou , Zhejiang , China.
Xuewei Daid Jingdezhen Center for Disease Control and Prevention , Jingdezhen , Jiangxi , China.
Jing Lic Zhejiang Provincial Hospital , Hangzhou , Zhejiang , China.
Ying Liub General Practice Department , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
Yan Qiub General Practice Department , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
Jingjing Renb General Practice Department , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
Zhejiang Center for Disease Control and Prevention · CNZhejiang University · CNJingdezhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune responses of isolated anti-HBc subjects are not well characterized in populations in China. This study aimed to evaluate immune responses to hepatitis B vaccination in isolated anti-HBc positive subjects. A cohort of 608 subjects were selected and separated into isolated anti-HBc (negative for HBsAg and anti-HBs, positive for anti-HBc) and control (negative for HBsAg, anti-HBs, and anti-HBc) groups, who were matched by age and sex. All subjects received 3 doses of hepatitis B vaccine (20μg) at months 0, 1, and 3, followed by testing for serological responses 1 month after the third vaccination. The positive seroprotection rate and geometric mean titer (GMT) for hepatitis B surface antibody (anti-HBs) of isolated anti-HBc subjects were significantly lower than those in the control group(86.2% vs.92.1%, P = 0.02; 47.26 vs.97.81 mIU/mL, P < 0.001). When stratified by age, positive seroprotection rate in the isolated anti-HBc group were 92%, 88.5% and 79.4% in the 20-34, 35-49, and 50-60 y old subgroups, respectively (χ2 = 5.919, P = 0.04). Additionally, the GMT level for anti-HBs in the isolated anti-HBc group for different age subgroups were 104.43, 47.87 and 31.79 mIU/mL respectively (χ2 = 19.44, P < 0.001). The GMT level for anti-HBc before vaccination were negatively correlated with GMT for anti-HBs after 3 doses of hepatitis B vaccine (r = -0.165, P < 0.001). In conclusion, isolated anti-HBc positive subjects can achieve good immune responses after hepatitis B vaccination, and the positive seroprotection rate and GMT level for anti-HBs were lower than the control group. Better responses could be observed in young adults, and significant negative correlations were found between GMT of anti-HBc before vaccination and GMT of anti-HBs after vaccination.

Indexed as

Adaptive ImmunityAdultChinaFemaleHepatitis B AntibodiesHepatitis B Core AntigensHepatitis B Surface AntigensHepatitis B VaccinesHumansMaleMiddle AgedHepatitis B AntibodiesHepatitis B Core AntigensHepatitis B Surface AntigensHepatitis B Vaccineshepatitis B virusisolated anti-HBcvaccine

Identifiers

PMID27065099
PMCPMC4964834
OpenAlexW2322593347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.