ArticleFrontiers in aging neuroscience2016
Voxel-Wise Meta-Analysis of Gray Matter Changes in Amyotrophic Lateral Sclerosis.
Article in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Voxel-based meta-analysis of gray matter and white matter changes in patients with spinocerebellar ataxia type 3.Frontiers in neurology · 2023Pooled it
- A Voxel-Wise Meta-Analysis on the Cerebellum in Essential Tremor.Medicina (Kaunas, Lithuania) · 2021Pooled it
- The Frontal Aslant Tract: A Systematic Review for Neurosurgical Applications.Frontiers in neurology · 2021Pooled it
- Comparison of Gray Matter Atrophy in Behavioral Variant Frontal Temporal Dementia and Amyotrophic Lateral Sclerosis: A Coordinate-Based Meta-Analysis.Frontiers in aging neuroscience · 2020Pooled it
- Voxel-based meta-analysis of gray and white matter volume abnormalities in spinocerebellar ataxia type 2.Brain and behavior · 2018Pooled it
- Brain Folding Trajectories in Amyotrophic Lateral Sclerosis.Human brain mapping · 2026Article
- Article
- Mapping Neuroimaging Findings of Creativity and Brain Disease Onto a Common Brain Circuit.JAMA network open · 2025Article
- Cortical microstructural abnormalities in amyotrophic lateral sclerosis: a gray matter-based spatial statistics study.Quantitative imaging in medicine and surgery · 2024Article
- Drooling disrupts the brain functional connectivity network in Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- Editorial Comment: Iron-sensitive MR imaging of the primary motor cortex to differentiate hereditary spastic paraplegia from other motor neuron diseases.European radiology · 2022Article
- Distinct patterns of progressive gray and white matter degeneration in amyotrophic lateral sclerosis.Human brain mapping · 2022Article
- Pathophysiological Underpinnings of Extra-Motor Neurodegeneration in Amyotrophic Lateral Sclerosis: New Insights From Biomarker Studies.Frontiers in neurology · 2021Review
- Feature selection from magnetic resonance imaging data in ALS: a systematic review.Therapeutic advances in chronic disease · 2021Review
- Frontotemporal Pathology in Motor Neuron Disease Phenotypes: Insights From Neuroimaging.Frontiers in neurology · 2021Review
- Alterations of Regional Homogeneity in the Mild and Moderate Stages of Parkinson's Disease.Frontiers in aging neuroscience · 2021Article
- Cortical microstructure in the amyotrophic lateral sclerosis-frontotemporal dementia continuum.Neurology · 2020Article
- Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis.Neurobiology of disease · 2020Review
- A Systematic Review of Genotype-Phenotype Correlation across Cohorts Having Causal Mutations of Different Genes in ALS.Journal of personalized medicine · 2020Review
- Cerebral atrophy in amyotrophic lateral sclerosis parallels the pathological distribution of TDP43.Brain communications · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreasing neuroimaging studies have revealed gray matter (GM) anomalies of several brain regions by voxel-based morphometry (VBM) studies in patients with amyotrophic lateral sclerosis (ALS). A voxel-wise meta-analysis was conducted to integrate the reported studies to determine the consistent GM alterations in ALS based on VBM methods.
methodsOvid Medline, Pubmed, Emabase, and BrainMap database were searched for relevant studies.Data were extracted by two independent researchers. Voxel-wise meta-analysis was performed using the effect-size signed differential mapping (ES-SDM) software.
resultsTwenty-nine VBM studies comprising 638 subjects with ALS and 622 healthy controls (HCs) met inclusion criteria.The global GM volumes of ALS patients were significantly decreased compared with those of HCs. GM reductions in patients were mainly located in the right precentral gyrus, the left Rolandic operculum, the left lenticular nucleus and the right anterior cingulate/paracingulate gyri. The right precentral gyrus and the left inferior frontal gyrus might be potential anatomical biomarkers to evaluate the severity of the disease, and longer disease duration was associated with more GM atrophy in the left frontal aslant tract and the right precentral gyrus in ALS patients.
conclusionThe results support that ALS is a complex degenerative disease involving multisystems besides the motor system.The mechanism of asymmetric atrophy of the motor cortex and the implication of Rolandic operculum involvement in ALS need to be further elucidated in future studies.
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