Evidence map›Paper›PMID 27064345›Full record

ArticleFly2016

Novel mutants of the aubergine gene.

H Bahar Sahin, Omer Faruk Karatas, Valeria Specchia, Silvia Di Tommaso, Céline Diebold, Maria Pia Bozzetti, Angela Giangrande

Open access · bronzeAbstract read
In one paragraph

Article in Fly, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Frontiers in genetics · 2019
    Review
  5. Article
  6. dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster.International journal of molecular sciences · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

H Bahar Sahina IGBMC, CNRS UMR 7104 - Inserm U 964 . Illkirch Cedex / FRANCE.
Omer Faruk Karatasa IGBMC, CNRS UMR 7104 - Inserm U 964 . Illkirch Cedex / FRANCE.
Valeria Specchiad DiSTeBA - Department of Biological and Environmental Science and Technology - University of Salento - Lecce , Italy.
Silvia Di Tommasod DiSTeBA - Department of Biological and Environmental Science and Technology - University of Salento - Lecce , Italy.
Céline Diebolda IGBMC, CNRS UMR 7104 - Inserm U 964 . Illkirch Cedex / FRANCE.
Maria Pia Bozzettid DiSTeBA - Department of Biological and Environmental Science and Technology - University of Salento - Lecce , Italy.
Angela Giangrandea IGBMC, CNRS UMR 7104 - Inserm U 964 . Illkirch Cedex / FRANCE.
University of Salento · ITInstitut de génétique et de biologie moléculaire et cellulaire · FRErzurum Technical University · TRInserm · FR

Funding

Telethon GGP14181
6 · The paper itself

Abstract

Aubergine is an RNA-binding protein of the Piwi clade, functioning in germline in the piRNA pathway that silences transposons and repetitive sequences. Several mutations of this gene exist, but they mostly result in truncated proteins or correspond to mutations that also affect neighboring genes. We have generated complete aubergine knock-out mutants that do not disrupt the neighboring genes. These novel mutants are characterized by PCR and sequencing. Their nature is confirmed by female sterility and by the presence of crystals in testes, common to the aubergine loss of function mutations. These mutants provide novel and more appropriate tools for the study of the piRNA pathway that controls genome stability.

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsGene Knockout TechniquesMutationPeptide Initiation Factorsaub protein, DrosophilaDrosophila ProteinsPeptide Initiation FactorsargonauteAuberginecrystal-stellateknockout mutantmutagenesispiRNAsterility

Identifiers

PMID27064345
PMCPMC4934710
OpenAlexW2318405318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.