SynthesisNature genetics2016
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 7 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations.Genome medicine · 2026Pooled it
- GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphology.Nature communications · 2025Pooled it
- Linking Iris Cis-Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics.Investigative ophthalmology & visual science · 2024Pooled it
- Pooled it
- Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation.Cell reports. Medicine · 2024Pooled it
- Interaction of background genetic risk, psychotropic medications, and primary angle closure glaucoma in the UK Biobank.PloS one · 2022Pooled it
- Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.Nature genetics · 2018Pooled it
- An Integrated muti-omics cell atlas of the human trabecular meshwork and ciliary body.bioRxiv : the preprint server for biology · 2026Article
- Visual field progression in varying severities of treated patients with primary angle closure glaucoma.Scientific reports · 2026Article
- Cortical gradient compression links cognition and transcriptomic signatures in primary angle-closure glaucoma.Communications biology · 2026Article
- Exploring genetic diversity in genome-wide association studies and polygenic risk scores in the admixed Brazilian population.Genetics and molecular biology · 2026Article
- Mapping Multiscale Brain Changes in Primary Angle-Closure Glaucoma Using Regional Radiomics Similarity Networks.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Dual-Level Pattern Tree for Visual Field Improves Glaucoma Progression and Polygenic Risk Prediction.Translational vision science & technology · 2025Article
- Functionally deficient UBOX5 variants and primary angle-closure glaucoma.Nature communications · 2025Article
- Genetic Association of Primary Angle-Closure Glaucoma and Disease Progression.Clinical & experimental ophthalmology · 2025Article
- Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis-induced cytokine transcriptional responses.The Journal of clinical investigation · 2025Article
- FOXP4 Variants Are Associated With Plateau Iris and Angle Closure Glaucoma.Investigative ophthalmology & visual science · 2025Article
- Genetic association of single nucleotide polymorphisms in PLEKHA7 gene with primary angle closure glaucoma (PACG) in a Central-Eastern Punjab cohort of Pakistan.Molecular biology reports · 2025Article
- Exome sequencing in Asian populations identifies low-frequency and rare coding variation influencing Parkinson's disease risk.Nature aging · 2025Article
- Functional investigation suggests CNTNAP5 involvement in glaucomatous neurodegeneration obtained from a GWAS in primary angle closure glaucoma.PLoS genetics · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
229 authors.
Chiea Chuen KhorGenome Institute of Singapore, A-STAR, Singapore.
Tan DoVietnam National Institute of Ophthalmology, Hanoi, Vietnam.
Hongyan JiaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.
Masakazu NakanoDepartment of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ronnie GeorgeJadhavbhai Nathamal Singhvi Department of Glaucoma, Medical Research Foundation, Sankara Nethralaya, Chennai, India.ORCID http://orcid.org/0000-0001-7368-0252
Khaled Abu-AmeroDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Roopam DuveshDepartment of Genetics, Aravind Medical Research Foundation, Madurai, India.
Li Jia ChenDepartment of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China.
Zheng LiGenome Institute of Singapore, A-STAR, Singapore.ORCID http://orcid.org/0000-0002-7060-2213
Monisha E NongpiurSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Shamira A PereraSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Chunyan QiaoBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.
Hon-Tym WongDepartment of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore.
Hiroshi SakaiDepartment of Ophthalmology, University of the Ryukyus, Okinawa, Nishihara, Japan.
Mônica Barbosa de MeloCenter of Molecular Biology and Genetic Engineering, University of Campinas, Campinas, Brazil.
Mei-Chin LeeSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Anita S ChanSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Yaakub AzhanyDepartment of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia and Hospital Universiti Sains Malaysia, Kelantan, Malaysia.
Thi Lam Huong DaoVietnam National Institute of Ophthalmology, Hanoi, Vietnam.
Yoko IkedaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Rodolfo A Perez-GrossmannInstituto de Glaucoma y Catarata, Lima, Peru.
Tomasz ZarnowskiDepartment of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland.
Alexander C DayNIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.ORCID http://orcid.org/0000-0002-2099-8870
Jost B JonasDepartment of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University Heidelberg, Heidelberg, Germany.
Pancy O S TamDepartment of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China.
Tuan Anh TranHo Chi Minh City Eye Hospital, Ho Chi Minh City, Vietnam.
Humaira AyubDepartment of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.
Farah AkhtarPakistan Institute of Ophthalmology, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan.
Shazia MichealDepartment of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Paul T K ChewDepartment of Ophthalmology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Leyla A AljasimKing Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Tanuj DadaAll India Institute of Medical Sciences, New Delhi, India.
Tam Thi LuuDepartment of Glaucoma, Da Nang Eye Hospital, Da Nang City, Vietnam.
Mona S AwadallaDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
Naris KitnarongDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Boonsong WanichwecharungruangGlaucoma Services, Department of Ophthalmology, Rajavithi Hospital, Bangkok, Thailand.
Yee Yee AungMandalay Eye Department, Mandalay Eye ENT Hospital, University of Medicine Mandalay, Mandalay, Myanmar.
Jelinar Mohamed-NoorDepartment of Ophthalmology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Saravanan VijayanDepartment of Genetics, Aravind Medical Research Foundation, Madurai, India.
Sripriya SarangapaniVision Research Foundation, Sankara Nethralaya, Chennai, India.
Rahat HusainSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Aliza JapSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Mani BaskaranSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
David GohSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Daniel H SuSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Huaizhou WangBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.
Vernon K YongDepartment of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore.
Leonard W YipDepartment of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore.
Tuyet Bach TrinhHo Chi Minh City Eye Hospital, Ho Chi Minh City, Vietnam.
Manchima MakornwattanaDepartment of Ophthalmology, Thammasat University Faculty of Medicine, Rangsit, Thailand.
Thanh Thu NguyenEye Department, Viet Tiep General Hospital, Hai Phong, Vietnam.
Edgar U LeuenbergerAsian Eye Institute, Manila, Philippines.
Ki-Ho ParkDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Widya Artini WiyogoGlaucoma Service Jakarta Eye Center, Jakarta, Indonesia.
Rajesh S KumarNarayana Nethralaya Eye Hospital, Bangalore, India.
Celso TelloEinhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.
Yasuo KurimotoDepartment of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.
Suman S ThapaNepal Glaucoma Eye Clinic, Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
Kessara PathanapitoonDepartment of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
John F SalmonOxford Eye Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.
Yong Ho SohnDepartment of Ophthalmology, Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Seoul, Republic of Korea.
Antonio FeaDipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy.
Mineo OzakiOzaki Eye Hospital, Hyuga, Japan.
Jimmy S M LaiDepartment of Ophthalmology, University of Hong Kong, Hong Kong, China.
Visanee TantiseviDepartment of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chaw Chaw KhaingDepartment of Ophthalmology, No. 1 Defence Services General Hospital, Yangon, Myanmar.
Takanori MizoguchiMizoguchi Eye Hospital, Sasebo, Japan.
Satoko NakanoDepartment of Ophthalmology, Oita University Faculty of Medicine, Oita, Japan.
Chan-Yun KimDepartment of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Guangxian TangShijiazhuang First Eye Hospital, Shijiazhuang, China.
Sujie FanHandan Eye Hospital, Handan, China.
Renyi WuEye Institute and Affiliated Xiamen Eye Center, Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, China.
Hailin MengAnyang Eye Hospital, Anyang, China.
Thi Thuy Giang NguyenVietnam National Institute of Ophthalmology, Hanoi, Vietnam.
Tien Dat TranVietnam National Institute of Ophthalmology, Hanoi, Vietnam.
Morio UenoDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Jose Maria MartinezDepartment of Ophthalmology, Pasig City General Hospital, Pasig City, Philippines.
Norlina RamliUniversity of Malaya, Eye Research Centre, Kuala Lumpur, Malaysia.
Yin Mon AungMyanmar Eye Centre, Pun Hlaing Silom Hospital, Yangon, Myanmar.
Rigo Daniel ReyesDepartment of Ophthalmology/Glaucoma Section, Asian Hospital and Medical Center, Muntinlupa City, Philippines.
Stephen A VernonDepartment of Ophthalmology, University Hospital Nottingham, University of Nottingham, Nottingham, UK.
Seng Kheong FangInternational Specialist Eye Centre, Kuala Lumpur, Malaysia.
Zhicheng XieGenome Institute of Singapore, A-STAR, Singapore.
Xiao Yin ChenGenome Institute of Singapore, A-STAR, Singapore.
Jia Nee FooGenome Institute of Singapore, A-STAR, Singapore.ORCID http://orcid.org/0000-0001-9899-2308
Kar Seng SimGenome Institute of Singapore, A-STAR, Singapore.ORCID http://orcid.org/0000-0002-3822-7759
Tina T WongSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Desmond T QuekSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Rengaraj VenkateshGlaucoma Clinic, Aravind Eye Hospital, Pondicherry, India.
Srinivasan KavithaGlaucoma Clinic, Aravind Eye Hospital, Pondicherry, India.
Subbiah R KrishnadasGlaucoma Clinic, Aravind Eye Hospital, Madurai, India.
Nagaswamy SoumittraVision Research Foundation, Sankara Nethralaya, Chennai, India.
Balekudaru ShanthaJadhavbhai Nathamal Singhvi Department of Glaucoma, Medical Research Foundation, Sankara Nethralaya, Chennai, India.
Boon-Ang LimDepartment of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore.
Jeanne OgleDepartment of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore.
José P C de VasconcellosDepartment of Ophthalmology, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.
Vital P CostaGlaucoma Clinic, Aravind Eye Hospital, Madurai, India.
Ricardo Y AbeGlaucoma Clinic, Aravind Eye Hospital, Madurai, India.
Bruno B de SouzaCenter of Molecular Biology and Genetic Engineering, University of Campinas, Campinas, Brazil.
Chelvin C SngDepartment of Ophthalmology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Maria C AquinoDepartment of Ophthalmology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ewa Kosior-JareckaDepartment of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland.
Guillermo Barreto FongInstituto de Ciencias Médicas, Lima, Peru.
Vania Castro TamanajaHospital Nacional Arzobispo Loayza, Lima, Peru.
Ricardo FujitaCentro de Genética y Biología Molecular, Universidad de San Martín de Porres, Lima, Peru.
Yuzhen JiangNIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.
Naushin WaseemNIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.
Sancy LowNIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.
Huan Nguyen PhamHo Chi Minh City Eye Hospital, Ho Chi Minh City, Vietnam.
Sami Al-ShahwanKing Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
E Randy CravenKing Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Muhammad Imran KhanDepartment of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands.
Rrima DadaAll India Institute of Medical Sciences, New Delhi, India.
Kuldeep MohantyAll India Institute of Medical Sciences, New Delhi, India.
Muneeb A FaiqAll India Institute of Medical Sciences, New Delhi, India.
Alex W HewittMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Kathryn P BurdonDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0001-8217-1249
Eng Hui GanDepartment of Ophthalmology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Anuwat PrutthipongsitDepartment of Ophthalmology, Thammasat University Faculty of Medicine, Rangsit, Thailand.
Thipnapa PatthanathamrongkasemDepartment of Ophthalmology, Thammasat University Faculty of Medicine, Rangsit, Thailand.
Mary Ann T CatacutanAsian Eye Institute, Manila, Philippines.
Irene R FelarcaAsian Eye Institute, Manila, Philippines.
Chona S LiaoAsian Eye Institute, Manila, Philippines.
Emma RusmayaniGlaucoma Service Jakarta Eye Center, Jakarta, Indonesia.
Vira Wardhana IstiantoroGlaucoma Service Jakarta Eye Center, Jakarta, Indonesia.
Giulia ConsolandiDipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy.
Giulia PignataDipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy.
Carlo LaviaDipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy.
Prin RojanapongpunDepartment of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Lerprat MangkornkanokpongDepartment of Ophthalmology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Sunee ChansangpetchDepartment of Ophthalmology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Jonathan C H ChanDepartment of Ophthalmology, Queen Mary Hospital, Hong Kong, China.
Bonnie N K ChoyDepartment of Ophthalmology, University of Hong Kong, Hong Kong, China.
Jennifer W H ShumDepartment of Ophthalmology, University of Hong Kong, Hong Kong, China.
Hlaing May ThanDepartment of Ophthalmology, North Okkalarpa General Hospital, Yangon, Myanmar.
Khin Thida OoMyanmar Eye Centre, Pun Hlaing Silom Hospital, Yangon, Myanmar.
Aye Thi HanMyanmar Eye Centre, Pun Hlaing Silom Hospital, Yangon, Myanmar.
Victor H YongSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Xiao-Yu NgSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Shuang Ru GohSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Yaan Fun ChongSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Martin L HibberdGenome Institute of Singapore, A-STAR, Singapore.
Mark SeielstadInstitute for Human Genetics, University of California, San Francisco, San Francisco, California, USA.ORCID http://orcid.org/0000-0001-5783-1401
Eileen PngGenome Institute of Singapore, A-STAR, Singapore.
Sarah J DunstanOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.ORCID http://orcid.org/0000-0001-7873-933X
Nguyen Van Vinh ChauHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Jinxin BeiSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Yi Xin ZengSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Abhilasha KarkeyOxford University Clinical Research Unit-Nepal, Patan Academy of Health Sciences, Patan Hospital, Patan, Nepal.
Buddha BasnyatOxford University Clinical Research Unit-Nepal, Patan Academy of Health Sciences, Patan Hospital, Patan, Nepal.
Francesca PasuttoInstitute of Human Genetics, Friedrich Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Daniela PaoliDepartment of Ophthalmology, Monfalcone Hospital, Gorizia, Italy.
Paolo FrezzottiDepartment of Surgery, Section of Ophthalmology, University of Siena, Siena, Italy.
Jie Jin WangCentre for Vision Research, Department of Ophthalmology, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Paul MitchellCentre for Vision Research, Department of Ophthalmology, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
John H FingertDepartment of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
R Rand AllinghamSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Michael A HauserSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.ORCID http://orcid.org/0000-0003-2667-5420
Soon Thye LimDivision of Medical Oncology, National Cancer Centre, Singapore.
Soo Hong ChewDepartment of Economics, National University of Singapore, Singapore.
Richard P EbsteinDepartment of Psychology, National University of Singapore, Singapore.
Anavaj SakuntabhaiInstitut Pasteur, Functional Genetics of Infectious Diseases Unit, Department of Genomes and Genetics, Paris, France.
Kyu Hyung ParkDepartment of Ophthalmology, Seoul National University Bundang Hospital, Gyeonggi, Republic of Korea.
Jeeyun AhnDepartment of Ophthalmology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Greet BolandDepartment of Medical Microbiology and Virology, University Medical Center Utrecht, Utrecht, the Netherlands.
Harm SnippeDepartment of Medical Microbiology and Virology, University Medical Center Utrecht, Utrecht, the Netherlands.
Richard SteadDepartment of Ophthalmology, University Hospital Nottingham, University of Nottingham, Nottingham, UK.
Raquel QuinoDepartment of Ophthalmology/Glaucoma Section, Asian Hospital and Medical Center, Muntinlupa City, Philippines.
Su Nyunt ZawMyanmar Eye Centre, Pun Hlaing Silom Hospital, Yangon, Myanmar.
Urszula LukasikDepartment of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland.
Rohit ShettyNarayana Nethralaya Eye Hospital, Bangalore, India.
Mimiwati ZahariUniversity of Malaya, Eye Research Centre, Kuala Lumpur, Malaysia.
Hyoung Won BaeDepartment of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Nay Lin OoDepartment of Ophthalmology, No. 1 Defence Services General Hospital, Yangon, Myanmar.
Toshiaki KubotaDepartment of Ophthalmology, Oita University Faculty of Medicine, Oita, Japan.
Anita ManassakornDepartment of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Wing Lau HoDepartment of Ophthalmology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Laura DallortoDipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy.
Young Hoon HwangDepartment of Ophthalmology, Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Seoul, Republic of Korea.
Christine A KiireOxford Eye Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.
Masako KurodaDepartment of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.
Zeiras Eka DjamalGlaucoma Service Jakarta Eye Center, Jakarta, Indonesia.
Jovell Ian M PeregrinoAsian Eye Institute, Manila, Philippines.
Arkasubhra GhoshNarayana Nethralaya Eye Hospital, Bangalore, India.
Jin Wook JeoungDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Tung S HoanEye Department, Viet Tiep General Hospital, Hai Phong, Vietnam.
Nuttamon SrisamranDepartment of Ophthalmology, Thammasat University Faculty of Medicine, Rangsit, Thailand.
Thayanithi SandragasuDepartment of Ophthalmology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Saw Htoo SetMandalay Eye Department, Mandalay Eye ENT Hospital, University of Medicine Mandalay, Mandalay, Myanmar.
Vi Huyen DoanDepartment of Glaucoma, Da Nang Eye Hospital, Da Nang City, Vietnam.
Shomi S BhattacharyaDivision of Genetics, UCL Institute of Ophthalmology, London, UK.
Ching-Lin HoSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Donald T TanSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Ramanjit SihotaAll India Institute of Medical Sciences, New Delhi, India.
Seng-Chee LoonDepartment of Ophthalmology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Kazuhiko MoriDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Shigeru KinoshitaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Anneke I den HollanderDepartment of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Raheel QamarDepartment of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.
Ya-Xing WangBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Yik Y TeoGenome Institute of Singapore, A-STAR, Singapore.
E-Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Curt Hartleben-MatkinDepartment of Glaucoma, Institute of Ophthalmology 'Conde de Valenciana', Mexico City, Mexico.
David Lozano-GiralDepartment of Genetics, Institute of Ophthalmology 'Conde de Valenciana', Mexico City, Mexico.
Seang Mei SawSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Juan C ZentenoDepartment of Genetics, Institute of Ophthalmology 'Conde de Valenciana', Mexico City, Mexico.
Chi Pui PangDepartment of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China.
Huong T T BuiHo Chi Minh City Eye Hospital, Ho Chi Minh City, Vietnam.
Owen HeeDepartment of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore.
Jamie E CraigDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
Deepak P EdwardKing Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Michiko YonaharaDepartment of Ophthalmology, University of the Ryukyus, Okinawa, Nishihara, Japan.
Jamil Miguel NetoDepartment of Ophthalmology, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.
Maria L Guevara-FujitaCentro de Genética y Biología Molecular, Universidad de San Martín de Porres, Lima, Peru.
Liang XuBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Robert RitchEinhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.ORCID http://orcid.org/0000-0002-9368-7547
Ahmad Tajudin Liza-SharminiDepartment of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia and Hospital Universiti Sains Malaysia, Kelantan, Malaysia.
Tien Y WongSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Saleh Al-ObeidanDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Nhu Hon DoVietnam National Institute of Ophthalmology, Hanoi, Vietnam.
Periasamy SundaresanDepartment of Genetics, Aravind Medical Research Foundation, Madurai, India.
Clement C ThamDepartment of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China.
Paul J FosterNIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.
Lingam VijayaSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Kei TashiroDepartment of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Eranga N VithanaSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Ningli WangBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.
Tin AungSingapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.
Funding
Medical Research Council MR/K006584/1
Abstract
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10(-15)), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10(-16)), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10(-14)), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10(-11)), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10(-12)). We also confirmed significant association at three previously described loci (P < 5 × 10(-8) for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyCell LineChromosome MappingFemaleGene ExpressionGenetic LociGenotypeGlaucoma, Angle-ClosureHumansMale
Identifiers
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