Observational studyPediatric research2016
Nasogastric feeding tubes from a neonatal department yield high concentrations of potentially pathogenic bacteria- even 1 d after insertion.
Observational study in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Early Life Antibiotic Exposure and Intestinal Colonization by Enterobacteriaceae upon Admission to a Neonatal Referral Unit: A Case-Control Study.Antibiotics (Basel, Switzerland) · 2026Article
- ESBL-producingEpidemiology and infection · 2025Observational
- Genetic characteristics and risk factors of extended-spectrum β-lactamase-producingMicrobiology spectrum · 2025Observational
- Quality Improvement Project to Improve Adherence to Best Practices to Decrease Incidence of Necrotizing Enterocolitis in Preterm Infants.Children (Basel, Switzerland) · 2025Article
- Microbial Contamination of Percutaneous Endoscopic Gastrostomy Tube and Nasogastric Tube with Drug-Resistant Bacteria.Annals of nutrition & metabolism · 2025Article
- Construction of a risk prediction model for pulmonary infection in patients with spontaneous intracerebral hemorrhage during the recovery phase based on machine learning.Frontiers in neurology · 2025Article
- A Scoping Review of the Oral Microbiome in Preterm Infants.American journal of perinatology · 2024Article
- Linking preterm infant gut microbiota to nasograstric enteral feeding tubes: exploring potential interactions and microbial strain transmission.Frontiers in pediatrics · 2024Article
- Multidrug-resistant Gram-negative bacterial infections and associated factors in a Kenyan intensive care unit: a cross-sectional study.Annals of clinical microbiology and antimicrobials · 2023Article
- Used Nasogastric Feeding Tubes from Neonates Contain Infant-Specific Bacterial Profiles.Microorganisms · 2023Article
- Indications, Measurements, and Complications of Ten Essential Neonatal Procedures.International journal of pediatrics · 2023Review
- Article
- A comparison of bacterial colonization between nasogastric and orogastric enteral feeding tubes in infants in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Nasogastric enteral feeding tubes modulate preterm colonization in early life.Pediatric research · 2022Article
- Interspecies relationships between nosocomial pathogens associated to preterm infants and lactic acid bacteria in dual-species biofilms.Frontiers in cellular and infection microbiology · 2022Article
- Neonatal Feeding Tube Colonization and the Potential Effect on Infant Health: A Review.Frontiers in nutrition · 2022Review
- Article
- Clinical implications of preterm infant gut microbiome development.Nature microbiology · 2022Article
- Acquisition and Development of the Extremely Preterm Infant Microbiota Across Multiple Anatomical Sites.Journal of pediatric gastroenterology and nutrition · 2020Article
- Bacterial colonization and antimicrobial resistance genes in neonatal enteral feeding tubes.FEMS microbiology ecology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreterm infants are vulnerable to pathogens and at risk of developing necrotizing enterocolitis (NEC) or sepsis. Nasogastric feeding tubes (NG-tubes) might contaminate feeds given through them due to biofilm formation. We wanted to determine if there is a rationale in replacing NG-tubes more often to reduce contamination.
methodsWe conducted an observational study of used NG-tubes from a tertiary neonatal department. After removal, we flushed a 1-ml saline solution through the tube, determined the density of bacteria by culture, and related it to the duration of use and any probiotic administration through the tube.
resultsOut of the 94 NG-tubes, 89% yielded more than 1,000 colony-forming units (CFU)/ml bacteria, and 55% yielded the potentially pathogenic Enterobacteriaceae and/or Staphylococcus aureus. The mean concentration in the yield was 5.3 (SD: 2.1, maximum 9.4) log10CFU/ml. Neither the presence of contamination nor the density was associated with the time the NG-tube had been in use. Probiotic administration did not protect against contamination.
conclusionNG-tubes yielded high densities of bacteria even within the first day of use. Further studies are needed to determine if changing the NG-tubes between meals or once a day will make a positive impact on tube contamination and clinical parameters.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.