ArticleScientific reports2016
Hydrolases of the ILR1-like family of Arabidopsis thaliana modulate auxin response by regulating auxin homeostasis in the endoplasmic reticulum.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 71 citations in OpenAlex.
- Brassinosteroid signaling regulates PIN5/10-mediated intracellular auxin homeostasis to promote lateral root development in tomato.Plant communications · 2026Article
- Metabolism meets transport: a new perspective on auxin homeostasis at subcellular level.Planta · 2026Review
- GH3 phylogenetic subgroups define divergent routes of auxin inactivation via aspartate and glutamine conjugation.Plant physiology · 2026Article
- Bacillus endophyticus J13 imparts drought tolerance to Arabidopsis thaliana by regulating the plant auxin-dependent auxin conjugation pathway.Plant cell reports · 2025Article
- Cytosolic- and membrane-localized oxidized indole-3-acetic acid formation regulates developmental auxin transients.Plant physiology · 2025Article
- Diverse soil protists show auxin regulated growth in partnership with auxin-producing bacteria.The ISME journal · 2025Article
- Multi-omics analysis reveals the mechanism of adventitious roots formation in peach green branch cuttings.Frontiers in plant science · 2025Article
- Transcriptomic and hormonal dynamics in relation to adventitious rooting of two parentalFrontiers in plant science · 2025Article
- Slow release of a synthetic auxin induces formation of adventitious roots in recalcitrant woody plants.Nature biotechnology · 2024Article
- Transcriptomic and Physiological Analyses for the Role of Hormones and Sugar in Axillary Bud Development of Wild Strawberry Stolon.Plants (Basel, Switzerland) · 2024Article
- AtIAR1 is a Zn transporter that regulates auxin metabolism in Arabidopsis thaliana.Journal of experimental botany · 2024Article
- Transcriptome analysis unravels the biocontrol mechanism of Serratia plymuthica A30 against potato soft rot caused by Dickeya solani.PloS one · 2024Article
- Molecular regulation of apple and grape ripening: exploring common and distinct transcriptional aspects of representative climacteric and non-climacteric fruits.Journal of experimental botany · 2023Review
- Recent advances in auxin biosynthesis and homeostasis.3 Biotech · 2023Review
- Recent progress and perspectives on physiological and molecular mechanisms underlying cold tolerance of tea plants.Frontiers in plant science · 2023Review
- Long-term cold, freezing and drought: overlapping and specific regulatory mechanisms and signal transduction in tea plant (Frontiers in plant science · 2023Article
- Uncovering transcriptional reprogramming during callus development in soybean: insights and implications.Frontiers in plant science · 2023Article
- Multiomic Approaches Reveal Hormonal Modulation and Nitrogen Uptake and Assimilation in the Initial Growth of Maize Inoculated withPlants (Basel, Switzerland) · 2022Article
- Integrative omics approaches revealed a crosstalk among phytohormones during tuberous root development in cassava.Plant molecular biology · 2022Article
- Fourteen Stations of Auxin.Cold Spring Harbor perspectives in biology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amide-linked conjugates of indole-3-acetic acid (IAA) have been identified in most plant species. They function in storage, inactivation or inhibition of the growth regulator auxin. We investigated how the major known endogenous amide-linked IAA conjugates with auxin-like activity act in auxin signaling and what role ILR1-like proteins play in this process in Arabidopsis. We used a genetically encoded auxin sensor to show that IAA-Leu, IAA-Ala and IAA-Phe act through the TIR1-dependent signaling pathway. Furthermore, by using the sensor as a free IAA reporter, we followed conjugate hydrolysis mediated by ILR1, ILL2 and IAR3 in plant cells and correlated the activity of the hydrolases with a modulation of auxin response. The conjugate preferences that we observed are in agreement with available in vitro data for ILR1. Moreover, we identified IAA-Leu as an additional substrate for IAR3 and showed that ILL2 has a more moderate kinetic performance than observed in vitro. Finally, we proved that IAR3, ILL2 and ILR1 reside in the endoplasmic reticulum, indicating that in this compartment the hydrolases regulate the rates of amido-IAA hydrolysis which results in activation of auxin signaling.
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