ArticleJournal of neuroscience methods2016
A novel method for classifying cortical state to identify the accompanying changes in cerebral hemodynamics.
Article in Journal of neuroscience methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The neurogenesis of P1 and N1: A concurrent EEG/LFP study.NeuroImage · 2017Article
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Authors and funding
8 authors.
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Abstract
backgroundMany brain imaging techniques interpret the haemodynamic response as an indirect indicator of underlying neural activity. However, a challenge when interpreting this blood based signal is how changes in brain state may affect both baseline and stimulus evoked haemodynamics. NEW
methodWe developed an Automatic Brain State Classifier (ABSC), validated on data from anaesthetised rodents. It uses vectorised information obtained from the windowed spectral frequency power of the Local Field Potential. Current state is then classified by comparing this vectorised information against that calculated from state specific training datasets.
resultsThe ABSC identified two user defined brain states (synchronised and desynchronised), with high accuracy (∼90%). Baseline haemodynamics were found to be significantly different in the two identified states. During state defined periods of elevated baseline haemodynamics we found significant decreases in evoked haemodynamic responses to somatosensory stimuli. COMPARISON TO EXISTING
methodsState classification - The ABSC (∼90%) demonstrated greater accuracy than clustering (∼66%) or 'power threshold' (∼64%) methods of comparison. Haemodynamic averaging - Our novel approach of selectively averaging stimulus evoked haemodynamic trials by brain state yields higher quality data than creating a single average from all trials.
conclusionsThe ABSC can account for some of the commonly observed trial-to-trial variability in haemodynamic responses which arises from changes in cortical state. This variability might otherwise be incorrectly attributed to alternative interpretations. A greater understanding of the effects of cortical state on haemodynamic changes could be used to inform techniques such as general linear modelling (GLM), commonly used in fMRI.
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