ArticleActa biomaterialia2016
A tenascin-C mimetic peptide amphiphile nanofiber gel promotes neurite outgrowth and cell migration of neurosphere-derived cells.
Article in Acta biomaterialia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 83 citations in OpenAlex.
- Programming Hydrogel Mechanics via Sequence-Controlled Polymerization Using Peptide Self-Assembly.Journal of the American Chemical Society · 2026Article
- Supramolecular nanostructure mimics GDNF trophic effects in vitro on human dopaminergic neurons.NPJ Regenerative medicine · 2025Article
- Deciphering the complexity of enteric niches in Hirschsprung disease: from metaphorical insights to therapeutic transformation.Frontiers in pediatrics · 2025Review
- A supramolecular polymer-collagen microparticle slurry for bone regeneration with minimal growth factor.Biomaterials · 2023Article
- Tenascin CNature communications · 2023Article
- Photoactuating Artificial Muscles of Motor Amphiphiles as an Extracellular Matrix Mimetic Scaffold for Mesenchymal Stem Cells.Journal of the American Chemical Society · 2022Article
- Conformational switch and multiple supramolecular structures of a newly identified self-assembling protein-mimetic peptide fromFrontiers in chemistry · 2022Article
- Directing Axonal Growth: A Review on the Fabrication of Fibrous Scaffolds That Promotes the Orientation of Axons.Gels (Basel, Switzerland) · 2021Review
- Self-Assembling Hydrogel Structures for Neural Tissue Repair.ACS biomaterials science & engineering · 2021Review
- Synthesis, Characterization and Evaluation of Peptide Nanostructures for Biomedical Applications.Molecules (Basel, Switzerland) · 2021Review
- Spidroin Silk Fibers with Bioactive Motifs of Extracellular Proteins for Neural Tissue Engineering.ACS omega · 2021Article
- Superstructured Biomaterials Formed by Exchange Dynamics and Host-Guest Interactions in Supramolecular Polymers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Associations Between Tenascin-C and Testosterone Deficiency in Men with Major Depressive Disorder: A Cross-Sectional Retrospective Study.Journal of inflammation research · 2021Article
- Design of materials with supramolecular polymers.Progress in polymer science · 2020Review
- Biomimetic peptide self-assembly for functional materials.Nature reviews. Chemistry · 2020Article
- A mimetic peptide of α2,6-sialyllactose promotes neuritogenesis.Neural regeneration research · 2020Article
- The influence of microenvironment and extracellular matrix molecules in driving neural stem cell fate within biomaterials.Brain research bulletin · 2019Review
- The Tenascin-C-Derived Peptide VSWRAPTA Promotes Neuronal Branching Via Transcellular Activation of the Focal Adhesion Kinase (FAK) and the ERK1/2 Signaling Pathway In Vitro.Molecular neurobiology · 2019Article
- Biofunctionalized self-assembly of peptide amphiphile induces the differentiation of bone marrow mesenchymal stem cells into neural cells.Molecular and cellular biochemistry · 2019Article
- Peptide supramolecular materials for therapeutics.Chemical Society reviews · 2018Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
unlabelledBiomimetic materials that display natural bioactive signals derived from extracellular matrix molecules like laminin and fibronectin hold promise for promoting regeneration of the nervous system. In this work, we investigated a biomimetic peptide amphiphile (PA) presenting a peptide derived from the extracellular glycoprotein tenascin-C, known to promote neurite outgrowth through interaction with β1 integrin. The tenascin-C mimetic PA (TN-C PA) was found to self-assemble into supramolecular nanofibers and was incorporated through co-assembly into PA gels formed by highly aligned nanofibers. TN-C PA content in these gels increased the length and number of neurites produced from neurons differentiated from encapsulated P19 cells. Furthermore, gels containing TN-C PA were found to increase migration of cells out of neurospheres cultured on gel coatings. These bioactive gels could serve as artificial matrix therapies in regions of neuronal loss to guide neural stem cells and promote through biochemical cues neurite extension after differentiation. One example of an important target would be their use as biomaterial therapies in spinal cord injury. STATEMENT OF SIGNIFICANCE: Tenascin-C is an important extracellular matrix molecule in the nervous system and has been shown to play a role in regenerating the spinal cord after injury and guiding neural progenitor cells during brain development, however, minimal research has been reported exploring the use of biomimetic biomaterials of tenascin-C. In this work, we describe a selfassembling biomaterial system in which peptide amphiphiles present a peptide derived from tenascin-C that promotes neurite outgrowth. Encapsulation of neurons in hydrogels of aligned nanofibers formed by tenascin-C-mimetic peptide amphiphiles resulted in enhanced neurite outgrowth. Additionally, these peptide amphiphiles promoted migration of neural progenitor cells cultured on nanofiber coatings. Tenascin-C biomimetic biomaterials such as the one described here have significant potential in neuroregenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.