Evidence map›Paper›PMID 27063472›Full record

ArticleHuman pathology2016

Pericytic mimicry in well-differentiated liposarcoma/atypical lipomatous tumor.

Jia Shen, Swati Shrestha, P Nagesh Rao, Greg Asatrian, Michelle A Scott, Vi Nguyen, Paulina Giacomelli, Chia Soo, Kang Ting, Fritz C Eilber and 3 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Differential pericyte marker expression in craniofacial benign and malignant vascular tumors.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2023
    Article
  6. Review
  7. Adipogenesis in Different Body Depots and Tumor Development.Frontiers in cell and developmental biology · 2020
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jia ShenSchool of Dentistry, University of California, Los Angeles, CA 90095.
Swati ShresthaDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
P Nagesh RaoDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Greg AsatrianSchool of Dentistry, University of California, Los Angeles, CA 90095; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Michelle A ScottNationwide Children's Hospital, Columbus, OH 43205.
Vi NguyenDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Paulina GiacomelliDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Chia SooOrthopedic Hospital Research Center, University of California, Los Angeles, CA 90095; Department of Surgery, University of California, Los Angeles, Los Angeles, CA 90095.
Kang TingSchool of Dentistry, University of California, Los Angeles, CA 90095.
Fritz C EilberDepartment of Surgery, University of California, Los Angeles, Los Angeles, CA 90095.
Bruno PeaultOrthopedic Hospital Research Center, University of California, Los Angeles, CA 90095; Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Sarah M DryDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Aaron W JamesSchool of Dentistry, University of California, Los Angeles, CA 90095; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; Orthopedic Hospital Research Center, University of California, Los Angeles, CA 90095. Electronic address: Awjames@mednet.ucla.edu.
University of California, Los Angeles · USOrthopaedic Hospital · USNationwide Children's Hospital · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARION Xenofon CHATZIIOANNOU · 1985 to 2026
$134.5M
NELL-1 isoforms for the systemic treatment of osteoporosisK08AR068316 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JAMES, AARON W · 2015 to 2019
$534k
Medical Research Council G1000816NCI NIH HHS P30 CA016042NIAMS NIH HHS K08 AR068316
6 · The paper itself

Abstract

Pericytes are modified smooth muscle cells that closely enwrap small blood vessels, regulating and supporting the microvasculature through direct endothelial contact. Pericytes demonstrate a distinct immunohistochemical profile, including expression of smooth muscle actin, CD146, platelet-derived growth factor receptor β, and regulator of G-protein signaling 5. Previously, pericyte-related antigens have been observed to be present among a group of soft tissue tumors with a perivascular growth pattern, including glomus tumor, myopericytoma, and angioleiomyoma. Similarly, malignant tumor cells have been shown to have a pericyte-like immunoprofile when present in a perivascular location, seen in malignant melanoma, glioblastoma, and adenocarcinoma. Here, we examine well-differentiated liposarcoma specimens, which showed some element of perivascular areas with the appearance of smooth muscle (n = 7 tumors). Immunohistochemical staining was performed for pericyte antigens, including smooth muscle actin, CD146, platelet-derived growth factor receptor β, and regulator of G-protein signaling 5. Results showed consistent pericytic marker expression among liposarcoma tumor cells within a perivascular distribution. MDM2 immunohistochemistry and fluorescence in situ hybridization for MDM2 revealed that these perivascular cells were of tumor origin (7/7 tumors), whereas double immunohistochemical detection for CD31/CD146 ruled out an endothelial cell contribution. These findings further support the concept of pericytic mimicry, already established in diverse malignancies, and its presence in well-differentiated liposarcoma. The extent to which pericytic mimicry has prognostic significance in liposarcoma is as yet unknown.

Indexed as

Cell DifferentiationMolecular MimicryActinsAdultAgedBiomarkers, TumorBiopsyCD146 AntigenFemaleHumansImmunohistochemistryIn Situ Hybridization, FluorescenceLipomaLiposarcomaMaleMiddle AgedACTA2 protein, humanActinsBiomarkers, TumorCD146 AntigenMCAM protein, humanMDM2 protein, humanPDGFRB protein, humanProto-Oncogene Proteins c-mdm2Receptor, Platelet-Derived Growth Factor betaRGS5 protein, humanRGS ProteinsCD146LiposarcomaPDGFRβPericyteSMA

Identifiers

PMID27063472
PMCPMC4938739
OpenAlexW2312637127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.