ReviewOsteoarthritis and cartilage2016
Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus.
Review in Osteoarthritis and cartilage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Meniscal repair: The current state and recent advances in augmentation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Pooled it
- Why Hoop Tension Matters: A Biomechanical Perspective on Medial Meniscus Posterior Root Tears-A Narrative Review.Bioengineering (Basel, Switzerland) · 2025Review
- Therapeutic Controlled Release Strategies for Human Osteoarthritis.Advanced healthcare materials · 2025Review
- Medial Meniscus Posterior Root Tear: How Far Have We Come and What Remains?Medicina (Kaunas, Lithuania) · 2023Review
- Women's contribution to stem cell research for osteoarthritis: an opinion paper.Frontiers in cell and developmental biology · 2023Review
- Optimization of Meniscus Cell Transduction Using Lentivirus and Adeno-Associated Virus for Gene Editing and Tissue Engineering Applications.Cartilage · 2021Article
- Orthopaedic Gene Therapy: Twenty-Five Years On.JBJS reviews · 2021Article
- Microstructure Analysis and Reconstruction of a Meniscus.Orthopaedic surgery · 2021Article
- Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine.Tissue engineering and regenerative medicine · 2019Review
- [Effects of staurosporine on the contraction of self-assembled constructs of goat temporomandibular joint disc cells].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2019Article
- Platelet-derived growth factor-coated decellularized meniscus scaffold for integrative healing of meniscus tears.Acta biomaterialia · 2018Article
- Current Concepts in Meniscus Tissue Engineering and Repair.Advanced healthcare materials · 2018Review
- Human Knee Meniscus Regeneration Strategies: a Review on Recent Advances.Current osteoporosis reports · 2018Review
- Biochemical Stimulus-Based Strategies for Meniscus Tissue Engineering and Regeneration.BioMed research international · 2018Review
- Micromechanical anisotropy and heterogeneity of the meniscus extracellular matrix.Acta biomaterialia · 2017Article
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- Coculture of meniscus cells and mesenchymal stem cells in simulated microgravity.NPJ microgravity · 2017Article
- Short histological kaleidoscope - recent findings in histology. Part V. About tendons, ligaments, and cartilages.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
- Evaluation of culture conditions forConnective tissue researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Meniscal lesions are common problems in orthopaedic surgery and sports medicine, and injury or loss of the meniscus accelerates the onset of knee osteoarthritis (OA). Despite a variety of therapeutic options in the clinics, there is a critical need for improved treatments to enhance meniscal repair. In this regard, combining gene-, cell-, and tissue engineering-based approaches is an attractive strategy to generate novel, effective therapies to treat meniscal lesions. In the present work, we provide an overview of the tools currently available to improve meniscal repair and discuss the progress and remaining challenges for potential future translation in patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.