Evidence map›Paper›PMID 27063424›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2016

Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors.

Jennifer K Saucier-Sawyer, Young-Eun Seo, Alice Gaudin, Elias Quijano, Eric Song, Andrew J Sawyer, Yang Deng, Anita Huttner, W Mark Saltzman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 83 citations in OpenAlex.

  1. Spatiotemporal cancer controlNanomedicine (London, England) · 2026
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  20. Drug delivery to the central nervous system.Nature reviews. Materials · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jennifer K Saucier-SawyerDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Young-Eun SeoDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Alice GaudinDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Elias QuijanoDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Eric SongDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Andrew J SawyerDepartment of Pathology, Yale University, New Haven, CT 06520, USA.
Yang DengDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Anita HuttnerDepartment of Pathology, Yale University, New Haven, CT 06520, USA.
W Mark SaltzmanDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA. Electronic address: mark.saltzman@yale.edu.
Yale University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
CED of Nanoparticles Loading with Novel Agents for Improved Treatment of GliomasR01CA149128 · NCI · YALE UNIVERSITY · PI SALTZMAN, W. MARK · 2011 to 2020
$3.5M
Yale University Clinical and Translational Science Award ProgramTL1TR000141 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$720k
NCATS NIH HHS TL1 TR000141NCI NIH HHS R01 CA149128NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is a fatal brain tumor characterized by infiltration beyond the margins of the main tumor mass and local recurrence after surgery. The blood-brain barrier (BBB) poses the most significant hurdle to brain tumor treatment. Convection-enhanced delivery (CED) allows for local administration of agents, overcoming the restrictions of the BBB. Recently, polymer nanoparticles have been demonstrated to penetrate readily through the healthy brain when delivered by CED, and size has been shown to be a critical factor for nanoparticle penetration. Because these brain-penetrating nanoparticles (BPNPs) have high potential for treatment of intracranial tumors since they offer the potential for cell targeting and controlled drug release after administration, here we investigated the intratumoral CED infusions of PLGA BPNPs in animals bearing either U87 or RG2 intracranial tumors. We demonstrate that the overall volume of distribution of these BPNPs was similar to that observed in healthy brains; however, the presence of tumors resulted in asymmetric and heterogeneous distribution patterns, with substantial leakage into the peritumoral tissue. Together, our results suggest that CED of BPNPs should be optimized by accounting for tumor geometry, in terms of location, size and presence of necrotic regions, to determine the ideal infusion site and parameters for individual tumors.

Indexed as

ConvectionDrug Delivery SystemsAnimalsBrainBrain NeoplasmsCell Line, TumorGlioblastomaGreen Fluorescent ProteinsHumansLactic AcidMaleNanoparticlesPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRats, Inbred F344Rats, NudeGreen Fluorescent ProteinsLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerConvection-enhanced delivery (CED)Poly(lactide-co-glycolide)Polymer nanoparticles

Identifiers

PMID27063424
PMCPMC4893898
OpenAlexW2333399485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.