ArticleArchives of physical medicine and rehabilitation2016
Men and Women Demonstrate Differences in Early Functional Recovery After Total Knee Arthroplasty.
Article in Archives of physical medicine and rehabilitation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01190046 (Muscle Disuse and Contractile Dysfunction in the Elderly), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Muscle Disuse and Contractile Dysfunction in the Elderly
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The Time Course of Quadriceps Strength Recovery After Total Knee Arthroplasty Is Influenced by Body Mass Index, Sex, and Age of Patients: Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Restoring physical function after knee replacement: a cross sectional comparison of progressive strengthening vs standard physical therapy.Physiotherapy theory and practice · 2020Trial
- Sociodemographic Differences in Long-Term Function After Total Hip and Knee Arthroplasty: A Scoping Review.Orthopaedic surgery · 2025Article
- Review
- Females report worse outcomes than males one year after ventral hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Beyond Discharge Disposition: A Scoping Review on Sociodemographic Disparities in Rehabilitation Use After Hip and Knee Arthroplasty.Physical therapy · 2024Article
- Improvement Trajectories in Patient-Reported Outcomes Between Males and Females After Anterior Cruciate Ligament Reconstruction.Journal of athletic training · 2023Article
- What matters to patients following total knee arthroplasty? A grounded theory of adapting to a knee replacement.BMC musculoskeletal disorders · 2022Article
- Innate Immunity at the Core of Sex Differences in Osteoarthritic Pain?Frontiers in pharmacology · 2022Review
- Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data.Journal of clinical medicine · 2021Review
- Determination of reference intervals for knee motor functions specific to patients undergoing knee arthroplasty.PloS one · 2021Article
- Peripheral Nociception Is Associated with Voluntary Activation Deficits and Quadriceps Weakness Following Total Knee Arthroplasty.The Journal of bone and joint surgery. American volume · 2019Observational
- Article
- Clinical relevance of active straight leg raising, standing up, and walking after total knee arthroplasty in a cross-sectional study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2018Article
- Moderate-intensity resistance exercise alters skeletal muscle molecular and cellular structure and function in inactive older adults with knee osteoarthritis.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo investigate whether sex affects the trajectory of functional recovery after total knee arthroplasty (TKA).
designRetrospective analysis from a historical database containing data from 3 prospective clinical trials and a pilot study.
settingClinical laboratory setting.
participantsRecruitment across studies was restricted to patients who underwent an elective unilateral TKA for the treatment of osteoarthritis and were between 50 and 85 years of age (N=301).
interventionsAcross all 4 studies, patients received a TKA and physical therapy intervention. Measures of physical function and strength were assessed before TKA and 1, 3, and 6 months after TKA.
main outcome measuresUsing a repeated-measures maximum likelihood model, statistical inference was made to estimate the changes in outcomes from before surgery to 1, 3, and 6 months after TKA that were stratified by sex. Muscle strength was assessed during maximal isometric quadriceps and hamstrings contractions. Muscle activation was assessed in the quadriceps muscle. Physical function outcomes included timed Up and Go (TUG) test, stair climbing test, and 6-minute walk test (6MWT).
resultsWomen demonstrated less decline in quadriceps strength than did men at 1, 3, and 6 months after TKA (P<.04), whereas women demonstrated less decline in hamstrings strength 1 month after TKA (P<.0001). Women demonstrated a greater decline than did men on the TUG test (P=.001), stair climbing test (P=.004), and 6MWT (P=.001) 1 month after TKA. Sex differences in physical function did not persist at 3 and 6 months after TKA.
conclusionsSex affected early recovery of muscle and physical function in the first month after TKA. Women demonstrated better preservation of quadriceps strength but a greater decline on measures of physical function than did men.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.