Evidence map›Paper›PMID 27063351›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2016

Adoptive Transfer of Tracer-Alloreactive CD4

M L Miller, J Chen, M D Daniels, M G McKeague, Y Wang, D Yin, V Vu, A S Chong, M-L Alegre

Open access · greenAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Low-affinity CD8American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  2. Article
  3. Article
  4. Resilience of T cell-intrinsic dysfunction in transplantation tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  5. Article
  6. Selective CD28 Blockade Results in Superior Inhibition of Donor-Specific T Follicular Helper Cell and Antibody Responses Relative to CTLA4-Ig.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  7. Review
  8. Article
  9. Antigen Presentation in Transplantation.Trends in immunology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

M L MillerSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL.
J ChenSection of Transplantation, Department of Surgery, University of Chicago, Chicago, IL.
M D DanielsSection of Transplantation, Department of Surgery, University of Chicago, Chicago, IL.
M G McKeagueSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL.
Y WangSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL.
D YinSection of Transplantation, Department of Surgery, University of Chicago, Chicago, IL.
V VuSection of Transplantation, Department of Surgery, University of Chicago, Chicago, IL.
A S ChongSection of Transplantation, Department of Surgery, University of Chicago, Chicago, IL.
M-L AlegreSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL.
University of Chicago · US

Funding

T cell mechanisms that distinguish robust tolerance from metastable allograft acceptance and failed tolerance (Project 2)P01AI097113 · NIAID · UNIVERSITY OF CHICAGO · PI Maria-Luisa Alegre, Anita S Chong · 2012 to 2026
$23.8M
CARDIOVASCULAR PATHOPHYSIOLOGY &BIOCHEMISTRY TRAININGT32HL007237 · NHLBI · UNIVERSITY OF CHICAGO · PI GETZ, GODFREY SHALOM · 1985 to 2011
$5.0M
Howard Hughes Medical Institute 56006772NHLBI NIH HHS T32 HL007237NIAID NIH HHS P01 AI097113
6 · The paper itself

Abstract

T cell receptor transgenic (TCR-Tg) T cells are often used as tracer populations of antigen-specific responses to extrapolate findings to endogenous T cells. The extent to which TCR-Tg T cells behave purely as tracer cells or modify the endogenous immune response is not clear. To test the impact of TCR-Tg T cell transfer on endogenous alloimmunity, recipient mice were seeded with CD4

Indexed as

Heart TransplantationAdoptive TransferAllograftsAnimalsAntigen-Presenting CellsCD4-Positive T-LymphocytesGraft RejectionIsoantibodiesLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicReceptors, Antigen, T-CellT-Lymphocyte SubsetsIsoantibodiesReceptors, Antigen, T-Cellalloantibodyalloantigenanimal models: murinebasic (laboratory) research/scienceheart transplantation/cardiologyimmunobiologyrejection: acuteT cell biology

Identifiers

PMID27063351
PMCPMC5065388
OpenAlexW2317176045

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.