ArticleScientific reports2016
Combined effects of physical exercise and education on age-related cortical thinning in cognitively normal individuals.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Higher VOScientific reports · 2021Trial
- Effect of aerobic exercise on cognition in younger adults: A randomized clinical trial.Neurology · 2019Trial
- Differential brain reorganization in chronic cervical spinal cord injury and its relation to motor versus sensory impairments: a preliminary investigation.Scientific reports · 2026Article
- Dissecting causal relationships between cortical morphology and neuropsychiatric disorders: a bidirectional Mendelian randomization study.Nature. Mental health · 2025Article
- Temporal Interactions between Maintenance of Cerebral Cortex Thickness and Physical Activity from an Individual Person Micro-Longitudinal Perspective and Implications for Precision Medicine.Journal of personalized medicine · 2024Article
- The Effect of Computerized Cognitive Training, with and without Exercise, on Cortical Volume and Thickness and Its Association with Gait Speed in Older Adults: A Secondary Analysis of a Randomized Controlled Trial.Journal of Alzheimer's disease reports · 2024Article
- Relationship between physical activity and cerebral white matter hyperintensity volumes in older adults with depressive symptoms and mild memory impairment: a cross-sectional study.Frontiers in aging neuroscience · 2024Article
- Cross-sectional associations between cortical thickness and physical activity in older adults with spontaneous memory complaints: The MAPT Study.Journal of sport and health science · 2023Article
- Different effects of cardiometabolic syndrome on brain age in relation to gender and ethnicity.Alzheimer's research & therapy · 2023Article
- Brain structural co-development is associated with internalizing symptoms two years later in the ABCD cohort.Journal of behavioral addictions · 2023Article
- Decreased visual acuity is related to thinner cortex in cognitively normal adults: cross-sectional, single-center cohort study.Alzheimer's research & therapy · 2022Article
- Active Life for Brain Health: A Narrative Review of the Mechanism Underlying the Protective Effects of Physical Activity on the Brain.Frontiers in aging neuroscience · 2021Review
- Free-Living Physical Activity Measured With a Wearable Device Is Associated With Larger Hippocampus Volume and Greater Functional Connectivity in Healthy Older Adults: An Observational, Cross-Sectional Study in Northern Portugal.Frontiers in aging neuroscience · 2021Article
- Engagement in Lifestyle Activities is Associated with Increased Alzheimer's Disease-Associated Cortical Thickness and Cognitive Performance in Older Adults.Journal of clinical medicine · 2020Article
- Cortical thickness and its associations with age, total cognition and education across the adult lifespan.PloS one · 2020Article
- Age-related differences in functional brain network segregation are consistent with a cascade of cerebrovascular, structural, and cognitive effects.Network neuroscience (Cambridge, Mass.) · 2020Article
- Sex-specific relationship of cardiometabolic syndrome with lower cortical thickness.Neurology · 2019Article
- Characterizing the Molecular Architecture of Cortical Regions Associated with High Educational Attainment in Older Individuals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Distinct Brain Regions in Physiological and Pathological Brain Aging.Frontiers in aging neuroscience · 2019Article
- Risk Factors Associated with Cortical Thickness and White Matter Hyperintensities in Dementia Free Okinawan Elderly.Journal of Alzheimer's disease : JAD · 2018Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the association between self-reported physical exercise and cortical thickness in a large sample of cognitively normal individuals. We also determined whether a combination of physical exercise and education had more protective effects on age-related cortical thinning than either parameter alone. A total of 1,842 participants were included in this analysis. Physical exercise was assessed using a questionnaire regarding intensity, frequency, and duration. Cortical thickness was measured using a surface-based method. Longer duration of exercise (≥1 hr/day), but not intensity or frequency, was associated with increased mean cortical thickness globally (P-value = 0.013) and in the frontal regions (P-value = 0.007). In particular, the association of exercise with cortical thinning had regional specificity in the bilateral dorsolateral prefrontal, precuneus, left postcentral, and inferior parietal regions. The combination of higher exercise level and higher education level showed greater global and frontal mean thickness than either parameter alone. Testing for a trend with the combination of high exercise level and high education level confirmed this finding (P-value = 0.001-0.003). Our findings suggest that combined exercise and education have important implications for brain health, especially considering the paucity of known protective factors for age-related cortical thinning.
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