Evidence map›Paper›PMID 27063270›Full record

ReviewClinics in liver disease2016

Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children.

David E Kleiner, Hala R Makhlouf

Open access · hybridAbstract readReview
In one paragraph

Review in Clinics in liver disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 3 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 3 syntheses or guidelines pooled it, 297 citations in OpenAlex.

  1. Pooled it
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  17. Determinants of Liver Steatosis Progression in Chinese Children: A Prospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Article
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  19. Article
  20. Review

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

David E KleinerLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Building 10, Room 2S235, MSC 1500, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: kleinerd@mail.nih.gov.
Hala R MakhloufCancer Diagnosis Program, Pathology Investigation and Resources Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, 9609 Medical Center Drive, Room 4W438, Bethesda, MD 20892, USA; Department of Pathology, Ain Shams University, Faculty of Medicine, 38 Al Abbassyah, Cairo, Greater Cairo 11566, Egypt.
Ain Shams University · EGNational Cancer Institute · US

Funding

Postmortem PathologyZICBC010685 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLEINER, DAVID ERWIN · 2009 to 2025
$14.3M
Postmortem PathologyZ01BC010685 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLEINER, DAVID E · 2005 to 2008
$913k
Intramural NIH HHS Z01 BC010685
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the liver disease associated with obesity, diabetes, and the metabolic syndrome. Although steatosis is a key histologic feature, liver biopsies of patients with NAFLD can show a wide range of findings. Nonalcoholic steatohepatitis (NASH) is a progressive subtype of NAFLD first defined by analogy to alcoholic hepatitis. Young children may have an alternate pattern of progressive NAFLD characterized by a zone 1 distribution of steatosis, inflammation, and fibrosis. Several grading and staging systems exist, but all require adequate biopsies. Although NASH generally shows fibrosis progression over time, some patients show regression of disease.

Indexed as

AdolescentAdultBiopsyChildHumansLiverLiver CirrhosisNon-alcoholic Fatty Liver DiseaseObserver VariationHistologyLiver biopsyScoringStagingSteatohepatitisSteatosis

Identifiers

PMID27063270
PMCPMC4829204
OpenAlexW2271384303

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.