Evidence map›Paper›PMID 27063267›Full record

ReviewClinics in liver disease2016

Nonalcoholic Fatty Liver Disease: Lipids and Insulin Resistance.

Paul D Berk, Elizabeth C Verna

Open access · greenAbstract readReview
In one paragraph

Review in Clinics in liver disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
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  7. A study on the treatment effects ofFrontiers in veterinary science · 2024
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  11. Review
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  19. Metabolic comparison of one-anastomosis gastric bypass, single-anastomosis duodenal-switch, Roux-en-Y gastric bypass, and vertical sleeve gastrectomy in rat.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Paul D BerkDivision of Digestive and Liver Diseases, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University Medical Center, 650 West 168 Street, New York, NY 10032, USA; Division of Preventive Medicine, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University Medical Center, William Black Building, 650 West 168 Street, Room 1006, Box 57A, New York, NY 10032, USA. Electronic address: pb2158@cumc.columbia.edu.
Elizabeth C VernaDivision of Digestive and Liver Diseases, Department of Medicine, Columbia College of Physicians and Surgeons, Columbia University Medical Center, 650 West 168 Street, New York, NY 10032, USA.
Columbia University · USColumbia University Irving Medical Center · US

Funding

RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Bariatric Surgery: Outcomes & Impact on PathophysiologyU01DK066667 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI BERK, PAUL DAVID, POMP, ALFONS · 2003 to 2015
$4.7M
FACILITATED UPTAKE OF LONG CHAIN FATTY ACIDS IN OBESITYR01DK052401 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI BERK, PAUL DAVID · 1998 to 2008
$2.6M
Bariatric Surgery for Morbid Obesity: Clinical and Pathophysiologic ConsequencesR01DK072526 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BERK, PAUL DAVID · 2006 to 2010
$1.8M
NIDDK NIH HHS 5U01DK066667-11NIDDK NIH HHS P30 DK026687NIDDK NIH HHS R01 DK052401NIDDK NIH HHS R01 DK072526NIDDK NIH HHS U01 DK066667
6 · The paper itself

Abstract

Obesity and its major comorbidities, including type 2 diabetes mellitus, nonalcoholic fatty liver disease (NAFLD), obesity cardiomyopathy, and certain cancers, have caused life expectancy in the United States to decline in recent years. Obesity is the increased accumulation of triglycerides (TG), which are synthesized from glycerol and long-chain fatty acids (LCFA) throughout the body. LCFA enter adipocytes, hepatocytes, and cardiomyocytes via specific, facilitated transport processes. Metabolism of increased cellular TG content in obesity may lead to comorbidities such as NAFLD and cardiomyopathy. Better understanding of LCFA transport processes may lead to successful treatment of obesity and NAFLD.

Indexed as

Insulin ResistanceAnimalsDisease Models, AnimalFatty AcidsHumansLeptinNon-alcoholic Fatty Liver DiseaseObesityPeptide HormonesTriglyceridesFatty AcidsLeptinPeptide HormonesSPX protein, humanTriglyceridesFacilitated transportLeptinLipotoxicitySpexinWeight regain

Identifiers

PMID27063267
PMCPMC4830921
OpenAlexW2336496894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.