ReviewNature reviews. Neurology2016
Neuropsychiatric sequelae of stroke.
Review in Nature reviews. Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 102 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Y-3 Injection in the Treatment of Acute Ischemic Stroke Phase II Clinical Trial -- Multicenter, Randomized, Double-blind, Parallel, Placebo-controlled Phase II Clinical Trial
A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Y-3 in Chinese Subjects With Acute Ischemic Stroke
Who cites it
102 citing papers in PubMed, 3 syntheses or guidelines pooled it, 221 citations in OpenAlex.
- Group Psychosocial Interventions Following Acquired Brain Injury: A Systematic Review and Meta-analysis of Group Process and Outcomes.Neuropsychology review · 2026Pooled it
- Effects of repetitive transcranial magnetic stimulation on sequelae in patients with chronic stroke: A systematic review and meta-analysis of randomized controlled trials.Frontiers in neuroscience · 2022Pooled it
- Poststroke psychosis: a systematic review.Journal of neurology, neurosurgery, and psychiatry · 2018Pooled it
- Loberamisal injection for the treatment of acute ischaemic stroke: a multicentre, randomised, double-blind, placebo-controlled phase II clinical trial.Stroke and vascular neurology · 2026Trial
- Trial
- A Mobile Health App for the Collection of Functional Outcomes After Inpatient Stroke Rehabilitation: Pilot Randomized Controlled Trial.JMIR mHealth and uHealth · 2020Trial
- Latent Profiles of Post-Stroke Fatigue and Their Association with Anxiety, Depression, and Sleep in Patients with First-Ever Stroke: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Unpacking neuropsychiatry and behavioural neurology training: scoping review of core syllabus components.BJPsych bulletin · 2026Article
- Antipsychotics and Their Association With Long-Term Outcomes in Young Ischemic Stroke Patients.European journal of neurology · 2026Article
- Circulating IncRNAs and Their Association With Ischemic Stroke Severity and Prognosis: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Early prediction of post-stroke depression using polysomnography parameters: a prospective cohort study.Frontiers in neuroscience · 2026Article
- Working years lost in people with epilepsy according to underlying aetiology: a population-based cohort study.BMJ neurology open · 2026Article
- Elevated NHHR at admission is independently associated with elevated post-stroke depressive symptoms.Frontiers in psychiatry · 2026Article
- Enhancing acute stroke care in Ireland: A scoping review and Delphi consensus for the Irish National Audit of Stroke (INAS) dataset.BMJ open · 2025Article
- Reshaping life after stroke: a grounded theory.International journal of nursing studies advances · 2025Article
- Article
- Psychological outcomes and changes in health-related quality of life in young and middle-aged patients with first-onset stroke after rehabilitation training.Frontiers in psychiatry · 2025Article
- Association between malnutrition, depression, anxiety and fatigue after stroke in older adults: a cross-lagged panel analysis.Aging clinical and experimental research · 2024Article
- Propranolol as a Novel Therapeutic Approach for Post-Stroke Anxiety: A Clinical Review and Future Directions.Cureus · 2024Review
- Functional Recovery in Acute and Subacute Stroke Patients With or Without Post-stroke Fatigue.Brain & NeuroRehabilitation · 2024Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke survivors are often affected by psychological distress and neuropsychiatric disturbances. About one-third of stroke survivors experience depression, anxiety or apathy, which are the most common neuropsychiatric sequelae of stroke. Neuropsychiatric sequelae are disabling, and can have a negative influence on recovery, reduce quality of life and lead to exhaustion of the caregiver. Despite the availability of screening instruments and effective treatments, neuropsychiatric disturbances attributed to stroke are currently underdiagnosed and undertreated. Stroke severity, stroke-related disabilities, cerebral small vessel disease, previous psychiatric disease, poor coping strategies and unfavourable psychosocial environment influence the presence and severity of the psychiatric sequelae of stroke. Although consistent associations between psychiatric disturbances and specific stroke locations have yet to be confirmed, functional MRI studies are beginning to unveil the anatomical networks that are disrupted in stroke-associated psychiatric disorders. Evidence regarding biochemical and genetic biomarkers for stroke-associated psychiatric disorders is still limited, and better understanding of the biological determinants and pathophysiology of these disorders is needed. Investigation into the management of these conditions must be continued, and should include pilot studies to assess the benefits of innovative behavioural interventions and large-scale cooperative randomized controlled pharmacological trials of drugs that are safe to use in patients with stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.