ArticleMedical hypotheses2016
Melanoma exosomes enable tumor tolerance in lymph nodes.
Article in Medical hypotheses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Focal adhesion kinase/Src family kinase axis-mediated tyrosine phosphorylation of metabolic enzymes facilitates tumor metastasis.Signal transduction and targeted therapy · 2025Article
- Melanoma-derived extracellular vesicles transfer proangiogenic factors.Oncology research · 2025Review
- Extracellular Vesicles Derived from Acidified Metastatic Melanoma Cells Stimulate Growth, Migration, and Stemness of Normal Keratinocytes.Biomedicines · 2022Article
- Exosome application in tumorigenesis: diagnosis and treatment of melanoma.Medical oncology (Northwood, London, England) · 2022Review
- Mechanisms of extracellular vesicle-mediated immune evasion in melanoma.Frontiers in immunology · 2022Review
- The potential role of tumor-derived exosomes in diagnosis, prognosis, and response to therapy in cancer.Expert opinion on biological therapy · 2021Article
- Exosomes: Emerging Cell-Free Based Therapeutics in Dermatologic Diseases.Frontiers in cell and developmental biology · 2021Review
- The Non-Coding Landscape of Cutaneous Malignant Melanoma: A Possible Route to Efficient Targeted Therapy.Cancers · 2020Review
- Extracellular Vesicles and Epigenetic Modifications Are Hallmarks of Melanoma Progression.International journal of molecular sciences · 2019Review
- Exosomes in melanoma: a role in tumor progression, metastasis and impaired immune system activity.Oncotarget · 2018Review
- Exosomes as a novel pathway for regulating development and diseases of the skin.Biomedical reports · 2018Article
- Exosome mediated multidrug resistance in cancer.American journal of cancer research · 2018Review
- A new bioluminescent reporter system to study the biodistribution of systematically injected tumor-derived bioluminescent extracellular vesicles in mice.Oncotarget · 2017Article
- Review
- Melanoma exosome induction of endothelial cell GM-CSF in pre-metastatic lymph nodes may result in different M1 and M2 macrophage mediated angiogenic processes.Medical hypotheses · 2016Article
- Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in Melanoma.Frontiers in oncology · 2016Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Melanoma preferentially spreads via lymph nodes. Melanoma exosomes can induce angiogenesis and immune suppression. However, a role for melanoma exosomes in facilitating tumor tolerance in lymph nodes has not been considered. Herein, the hypothesis that melanoma exosome mediated induction of vascular endothelial cell (VEC) derived tumor necrosis factor alpha (TNF-α) results in lymphatic endothelial cell (LEC) mediated tumor tolerance is explored. To support this hypothesis, experiments involving ex vivo lymph node associated VECs, LECs, dendritic cells and T lymphocytes are proposed based upon a previously established fluorescent exosome lymph node trafficking model. The implication of the hypothesis in the context of melanoma exosome mediated induction of tumor tolerance in lymph nodes is then discussed.
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Registered trials
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