ArticleScientific reports2016
Comparative genetic characterization of Enteroaggregative Escherichia coli strains recovered from clinical and non-clinical settings.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
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- Comparative analysis of virulence gene profiles of Escherichia coli from human and non-human sources in Rivers State, Nigeria.Access microbiology · 2024Article
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- The population genetics of pathogenic Escherichia coli.Nature reviews. Microbiology · 2021Review
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- Identification and characterisation of enteroaggregative Escherichia coli subtypes associated with human disease.Scientific reports · 2020Article
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- Truncated Class 1 Integron Gene Cassette Arrays Contribute to Antimicrobial Resistance of DiarrheagenicBioMed research international · 2020Article
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- Antibiotic resistance pattern and molecular characterization of extended-spectrum β-lactamase producing enteroaggregativeInfection and drug resistance · 2018Article
- Structural and functional studies of Escherichia coli aggregative adherence fimbriae (AAF/V) reveal a deficiency in extracellular matrix binding.Biochimica et biophysica acta. Proteins and proteomics · 2017Article
- MetaMLST: multi-locus strain-level bacterial typing from metagenomic samples.Nucleic acids research · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The origin of pathogenic Enteroaggregative Escherichia coli (EAEC), a major causative agent of childhood diarrhea worldwide, remains ill-defined. The objective of this study was to determine the relative prevalence of EAEC in clinical and non-clinical sources and compare their genetic characteristics in order to identify strains that rarely and commonly cause human diarrhea. The virulence gene astA was commonly detectable in both clinical and non-clinical EAEC, while clinical isolates, but not the non-clinical strains, were consistently found to harbor other virulence factors such as aap (32%), aatA (18%) and aggR (11%). MLST analysis revealed the extremely high diversity of EAEC ST types, which can be grouped into three categories including: (i) non-clinical EAEC that rarely cause human infections; (ii) virulent strains recoverable in diarrhea patients that are also commonly found in the non-clinical sources; (iii) organisms causing human infections but rarely recoverable in the non-clinical setting. In addition, the high resistance in these EAEC isolates in particular resistance to fluoroquinolones and cephalosporins raised a huge concern for clinical EAEC infection control. The data from this study suggests that EAEC strains were diversely distributed in non-clinical and clinical setting and some of the clinical isolates may originate from the non-clinical setting.
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