Evidence map›Paper›PMID 27062709›Full record

ReviewMaturitas2016

Adrenergic signaling in heart failure and cardiovascular aging.

Gaetano Santulli, Guido Iaccarino

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Maturitas, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gaetano SantulliCollege of Physicians & Surgeons, Columbia University Medical Center, New York, NY, USA. Electronic address: gs2620@cumc.columbia.edu.
Guido IaccarinoDivision of Internal Medicine, Department of Medicine and Surgery, University of Salerno, Italy. Electronic address: giaccarino@unisa.it.

Funding

Targeting intracellular calcium leak as novel therapy for diabetesK99DK107895 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SANTULLI, GAETANO · 2015 to 2016
$176k
NIDDK NIH HHS K99 DK107895
6 · The paper itself

Abstract

Both cardiovascular disease and aging are associated with changes in the sympathetic nervous system. Indeed, mounting evidence indicates that adrenergic receptors are functionally involved in numerous processes underlying both aging and cardiovascular disorders, in particular heart failure. This article will review the pathophysiological role of the sympathetic nervous system in heart failure and cardiovascular aging.

Indexed as

AgingCardiovascular SystemHeart FailureHumansNorepinephrineReceptors, AdrenergicSignal TransductionSympathetic Nervous SystemNorepinephrineReceptors, AdrenergicAgingBeta adrenergic receptorsCardiovascular systemG protein-coupled receptor kinasesHeart failureMultimorbiditySympathetic nervous system

Identifiers

PMID27062709
PMCPMC5036981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.