ArticleCancer biomarkers : section A of Disease markers2016
Impact of plasma fibrinogen levels in benign and malignant soft tissue tumors.
Article in Cancer biomarkers : section A of Disease markers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 11 citations in OpenAlex.
- Diagnostic and Predictive Recurrence Value of Plasma Fibrinogen in Patients With Adrenocortical Carcinoma.Clinical Medicine Insights. Oncology · 2025Article
- Fibrinogen and tumors.Frontiers in oncology · 2024Review
- Transcriptome analysis of tumor-derived mesenchymal progenitor cells shows thatAnnals of translational medicine · 2022Article
- The clinical significance of preoperative serum fibrinogen levels and platelet counts in patients with gallbladder carcinoma.BMC gastroenterology · 2021Article
- Significance of coagulation and fibrinolysis markers for benign and malignant soft tissue tumors.BMC cancer · 2021Article
- Predictive Value of Preoperative Controlling Nutritional Status Score Combined with Fibrinogen-Albumin Ratio in Postoperative Local Recurrence-Free Survival of Patients with Retroperitoneal Liposarcoma.Cancer management and research · 2021Article
- Prognostic Significance of the Combination of Fibrinogen and Tumor Marker Index in Esophageal Squamous Cell Carcinoma Patients.OncoTargets and therapy · 2021Article
- Prognostic value of the fibrinogen/albumin ratio (FAR) in patients with operable soft tissue sarcoma.BMC cancer · 2018Article
- Prognostic role of plasma fibrinogen in patients with uterine leiomyosarcoma - a multicenter study.Scientific reports · 2017Article
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11 authors.
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Abstract
backgroundFibrinogen, a 340 kDa glycoprotein synthesized in the liver, is known to be involved in tumor angiogenesis, enlargement, and metastasis. Elevated plasma fibrinogen levels are associated with tumor progression in many cancer patients. However, there are no reports about differences in fibrinogen levels between benign and malignant soft tissue tumors.
objectivesThe purpose of this study was to clarify whether preoperative plasma fibrinogen levels can be used for differential diagnosis of benign or malignant soft tissue tumors.
methodsThe plasma fibrinogen levels from 102 primary soft tissue tumor patients were measured before biopsy or treatment. Fibrinogen levels were analyzed and compared to various clinical parameters.
resultsAccording to receiver operating characteristic (ROC) curve analysis, a threshold of serum fibrinogen of 315 mg/dL identified malignant patients with 60.9% sensitivity and 87.5% specificity. The diagnostic accuracy was evaluated by area under the curve (AUC: 0.805). Over 315 mg/dL of fibrinogen was associated with a significantly increased risk of malignancy by multiple logistic regression analysis (OR: 6.452, p= 0.0004).
conclusionsWe demonstrated that plasma fibrinogen levels have a relationship with tumor malignancy of soft tissue tumors. High fibrinogen levels can be a helpful subsidiary tool for the prediction of malignant soft tissue tumors with other diagnostic tools.
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